Copyright ©The Author(s) 2017.
World J Stem Cells. Dec 26, 2017; 9(12): 219-226
Published online Dec 26, 2017. doi: 10.4252/wjsc.v9.i12.219
Table 1 Criteria for severe aplastic anemia[1]
Peripheral blood, CBC findings
Granulocytes< 500/cu mm
Platelets< 20000/cu mm
Reticulocytes< 1%
Bone marrow biopsy findings
Hypoplasia< 25% of normal cellularity
25%-50% of normal cellularity with < 30% hematopoietic cells
Table 2 Summary of the clinical uses of mesenchymal stem cells in aplastic anemia
TreatmentInterventionGoal (s) of therapyOutcome
MSC as adjunct to HCTMSCs given in conjunction with hematopoietic stem cell transplantationTo prevent graft failure or shorten time to engraftmentImproved donor engraftment
MSC as monotherapyMSCs given aloneFor primary treatment of AAPartial response in some patients