Haploidentical vs cord blood transplantation for adults with acute myelogenous leukemia

Table 1 Hematopoietic cell transplantation after myeloablative conditioning in adult patients comparing umbilical cord blood and other donor sources

Year	Graft type	Number of patients	Median age	ANC > 500/μL (median, d)	aGVHD II-IV(%)	Extensive cGVHD (%)	100 d TRM (%)	Relapse rate (%)	Survival (%)
2004[5]	UCB	150	16-60	27	41	51	63	17 (3 yr)	26 (3 yr)
	MUD BM	367	16-60	20	48	35	46	23	35
	MMUD BM	83	16-60	18	51	40	65	14	20
2004[6]	UCB	98	25	26	26	30	44	23 (2 yr)	36 (2 yr)
	MUD BM	584	32	19	39	46	38	13	42
2007[19]	UCB	100	38	22	60	23	8	17 (3 yr)	NA
	MRD (BM and PB)	71	40	17	55	30	4	26
2008[10]	UCB	148	29	NA	NA	NA	41	26 (2 yr)	35 (2 yr)
	MUD PB	518	35	NA	NA	NA	27	30	45
	MMUD PB	210	NA	NA	NA	NA	42	24	36
	MUD BM	243	29	NA	NA	NA	26	28	48
	MMUD BM	111	NA	NA	NA	NA	37	26	38
2009[62]	UCB AML	173	38	NA	32	8	32 (2 yr)	31 (2 yr)	43 (2 yr)
	MUD BM	311	38	NA	35	20	22	24	60
	UCB ALL	114	34	NA	28	10	24	31	49
	MUD BM	222	32	NA	42	17	25	24	57
2010[15]	MRD	204	40	NA	65	47	24 (5 yr)	43 (5 yr)	NA
	MUD	152	31	NA	80	43	14	37	NA
	MMUD	52	31	NA	85	48	27	35	NA
	DUCB	128	25	NA	60	28	34	15	NA

ANC: Absolute neutrophil count; aGVHD: Acute graft versus host disease; cGVHD: Chronic graft versus host disease; TRM: Treatment related mortality; UCB: Umbilical cord blood; MUD: Matched unrelated donor; BM: Bone marrow; MMUD: Mismatched unrelated donor; NA: Not available; MRD: Matched related donor; PB: Peripheral blood stem cells; AML: Acute myeloid leukemia; ALL: Acute lymphoblastic leukemia; DUCB: Double umbilical cord blood.

Table 2 Haploidentical hematopoietic cell transplantation compared to transplantation from other graft sources

Year	Number of patients	Neutrophil engraftment (median d)	aGVHD II-IV (%)	cGVHD (%)	100 d NRM (%)	Relapse (2 yr)	Survival (%)
2002[63]	MUD BM 81	16	42	57	23	25	58 (2 yr OS)
	MMUD BM 58	15	33	51	45	26	34
	Haplo 48	14	46	50	42	42	21
2005[53]	Haplo-ALL 74	NA	8	NA	49	38	13 (2 yr LFS)
	UCB-ALL 91		26		41	23	36
	Haplo-AML 151		12		58	18	24
	UCB-AML 91		26		24	24	30
2009[48]	Haplo 56	54/56 (13)	27	23	13	22	68 (2 yr LFS)
	MRD 51	48/51 (12)	14	31	8	17	76

aGVHD: Acute graft versus host disease; cGVHD: Chronic graft versus host disease; NRM: Non-relapse mortality; AML: Acute myelogenous leukemia; ALL: Acute lymphoblastic leukemia; NA: Not available; HCT: Hematopoietic cell transplant; MUD: Matched unrelated donor; BM: Bone marrow; MMUD: Mismatched unrelated donor; Haplo: Haploidentical family donor; OS: Overall survival; LFS: Leukemia free survival; UCB: Umbilical cord blood; MRD: Matched related donor.