Glioblastoma stem cells: Molecular characteristics and therapeutic implications

doi:10.4252/wjsc.v6.i2.230

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 6, Issue 2

This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (9382)

All Articles published online

The chart showing PDF series, WORD series, HTML series, Figures (1-1) series, Tables (1-1) series.

Item

Count

PDF

512

WORD

376

HTML

5860

Figures (1-1)

258

Tables (1-1)

215

Sum=7221

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

1141

Download

1020

Sum=2161

Apr 26, 2014 (publication date) through Feb 3, 2025

Times Cited of This Article

Times Cited (52)

Journal Information of This Article

Publication Name

World Journal of Stem Cells

ISSN

1948-0210

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Review

World J Stem Cells. Apr 26, 2014; 6(2): 230-238
Published online Apr 26, 2014. doi: 10.4252/wjsc.v6.i2.230

Table 1 Major signaling pathways and their roles in glioblastoma stem cell biology

Signaling pathway	Function	Ref.
Self-renewal
Notch Signaling	Maintenance of GSCs	[50-57]
	Tumorsphere formation
	Tumorigenesis
	Asymmetric division
TGF-β Signaling	Regulation of self-renewal	[34,58]
TGF-β Signaling	Maintenance of perivascular GSCs	[34,58]
Sonic Hedgehog Signaling	Promotion of self-renewal and migration	[56,61-66]
	Upregulation of stem cell associated genes
	Tumorigenesis
Wnt/β-catenin Signaling	Self-renewal and maintenance of GSCs	[15,66-71]
	Tumorigenesis
	Associated with bad prognosis
PI3K/Akt Signaling	Promotion of GSC self-renewal in vitro	[41-44]
	Proliferation and survival of GSCs
	Tumorigenesis
MAPK Signaling	Proliferation and survival of GSCs	[41]
Differentiation
BMP Signaling	Inhibition of asymmetric division	[72-74]
BMP Signaling	Differentiation and proliferation block	[72-74]
Notch Signaling	Trans-differentiation to tumor-derived endothelium	[16]
TGF-β Signaling	Trans-differentiation to vascular pericytes	[17]

GSC: Glioblastoma stem cell; TGF: Transforming growth factor.

Citation: Bayin NS, Modrek AS, Placantonakis DG. Glioblastoma stem cells: Molecular characteristics and therapeutic implications. World J Stem Cells 2014; 6(2): 230-238
URL: https://www.wjgnet.com/1948-0210/full/v6/i2/230.htm
DOI: https://dx.doi.org/10.4252/wjsc.v6.i2.230