Nutrient sensing in intestinal stem cell: Linking dietary nutrients to cellular metabolic regulation

Table 1 Functional characteristics of lactic acid-producing bacterial strains in modulating intestinal homeostasis

Bacterial strains	Mechanism/pathway	Biological effects	Ref.
Bifidobacterium spp.	GPR81 signaling	Promoting ISCs proliferation	[36]
Lactobacillus amylovorus	GPR81-Wnt/β-catenin axis	Enhancing ISCs proliferation	[37]
Lactobacillus salivarius	SUCNR1-mitochondria axis	Activating ISCs activity	[40]
Lactobacillus paracasei VL8	Tryptophan microbial metabolism	Inducing ISCs differentiation	[41]
Lactobacillus delbrueckii	-	Expanding ISCs population	[42]
Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium lactis	-	Augmenting innate and adaptive immunity	[43]
Lactobacillus casei	-	Ameliorating intestinal injury	[44]
Lactobacillus reuteri	Wnt/β-catenin axis	Mitigating intestinal mucosal damage	[45]
Lactipianibacillus plantarum	-	Alleviating constipation	[46]
Lactipianibacillus plantarum HFY11	-	Suppressing colitis	[47]
Lacticaseibacillus paracasei JY06E, Lactobacillus gasseri JM1	-	Relieving constipation	[48]

GPR81: Gi-protein-coupled receptor 81; ISCs: Intestinal stem cells; SUCNR1: Succinate receptor 1.