Mesenchymal stem cell therapy in atherosclerosis: A bibliometric and visual analysis

Table 1 The top 10 countries/regions and institutions in the field of mesenchymal stem cell therapy for atherosclerosis

Rank	Country/region	Documents	Citations	Institution	Documents	Centrality
1	China	195	4797	Zhejiang University	16	0.19
2	United States	140	9989	University of London	14	0.03
3	United Kingdom	36	2778	Harvard University	12	0.13
4	Japan	32	1071	Shanghai Jiao Tong University	11	0.05
5	Italy	31	1584	King’s College London	11	0.02
6	Germany	27	1251	Sun Yat Sen University	10	0.04
7	Canada	17	524	Harvard Medical School	9	0.09
8	Korea	17	231	Institut National de la Sante et de la Recherche Medicale (Inserm)	9	0.07
9	Australia	16	667	University of California System	9	0.07
10	France	15	1553	Chinese Academy of Sciences	9	0.04

Table 2 The top 10 journals and co-cited journals in the field of mesenchymal stem cell therapy for atherosclerosis

Rank	Journal	Documents	Citations	JCR (2023)	Co-cited journal	Citations	JCR (2023)
1	Int J Mol Sci	16	227	Q1, 5.6	Circulation	1772	Q1, 37.8
2	Front Cardiovasc Med	15	341	Q2, 3.6	Circ Res	1690	Q1, 20.1
3	Stem Cell Res Ther	13	288	Q1, 7.5	Arterioscl Throm Vas	1347	Q1, 8.7
4	Arterioscl Throm Vas	10	699	Q1, 8.7	P Natl Acad Sci Usa	812	Q1, 11.1
5	Cells-Basel	9	81	Q2, 6	J Biol Chem	809	Q2, 4.8
6	Circ Res	9	1348	Q1, 20.1	Nature	743	Q1, 64.8
7	Plos One	9	209	Q2, 3.7	Plos One	724	Q2, 3.7
8	Cardiovasc Res	8	347	Q1, 10.9	J Clin Invest	684	Q1, 15.9
9	Atherosclerosis	7	275	Q2, 5.3	Science	530	Q1, 56.9
10	Biochem Bioph Res Co	6	270	Q3, 3.1	Cardiovasc Res	520	Q1, 10.9

Table 3 The top 10 authors and co-cited authors in the field of mesenchymal stem cell therapy for atherosclerosis

Rank	Author	Documents	Cited author	Documents	Centrality
1	Xu Qingbo	9	Libby P	84	0.08
2	Orekhov Alexander N	5	Ross R	54	0.16
3	Li Song	4	Wang Y	49	0.04
4	Li Mincai	4	Asahara T	48	0.19
5	Colmegna Ines	3	Pittenger MF	48	0.04
6	Broskey Nicholas T	3	Hu YH	41	0.06
7	Zhang Wei	3	Zhang Y	40	0.05
8	Houmard Joseph A	3	Li Q	37	0.03
9	Song Chunli	3	Liu Y	36	0.1
10	Yu Jun	3	Sata M	36	0.07

Table 4 The top 10 publications in the field of mesenchymal stem cell therapy for atherosclerosis

Rank	Title	Journal	Citations	Type	Year	Ref.
1	Vascular smooth muscle cells in atherosclerosis	Nat Rev Cardiol	887	Review	2019	[83]
2	KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis	Nat Med	726	Article	2015	[84]
3	Mechanobiology of YAP and TAZ in physiology and disease	Nat Rev Mol Cell Biol	710	Review	2017	[85]
4	Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease	Annu Rev Physiol	537	Review	2012	[86]
5	Pericytes. Morphofunction, interactions and pathology in a quiescent and activated mesenchymal cell niche	Histol Histopathol	451	Review	2009	[87]
6	Gold nanoparticles for photoacoustic imaging	Nanomedicine (Lond)	417	Review	2015	[88]
7	Bone marrow mesenchymal stem and progenitor cells induce monocyte emigration in response to circulating toll-like receptor ligands	Immunity	368	Article	2011	[89]
8	Biomedical applications of photoacoustic imaging with exogenous contrast agents	Ann Biomed Eng	306	Review	2012	[90]
9	Matrix metalloproteinases: inflammatory regulators of cell behaviors in vascular formation and remodeling	Mediators Inflamm	300	Review	2013	[91]
10	Physical and mechanical regulation of macrophage phenotype and function	Cell Mol Life Sci	296	Review	2015	[92]

Table 5 The top 10 co-cited references in the field of mesenchymal stem cell therapy for atherosclerosis

Rank	Title	Journal	Citations	Type	Year	Ref.
1	Exosomes derived from mesenchymal stem cells attenuate the progression of atherosclerosis in ApoE(-/-) mice via miR-let7 mediated infiltration and polarization of M2 macrophage	Biochem Biophys Res Commun	26	Article	2019	[93]
2	Vascular smooth muscle cells in atherosclerosis	Nat Rev Cardiol	22	Review	2019	[83]
3	Adventitial MSC-like cells are progenitors of vascular smooth muscle cells and drive vascular calcification in chronic kidney disease	Cell Stem Cell	21	Article	2016	[94]
4	Mesenchymal stem cells reduce murine atherosclerosis development	Sci Rep	16	Article	2015	[65]
5	Shedding light on the cell biology of extracellular vesicles	Nat Rev Mol Cell Biol	14	Review	2018	[95]
6	Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines	J Extracell Vesicles	14	Guidelines	2018	[96]
7	Extensive proliferation of a subset of differentiated, yet plastic, medial vascular smooth muscle cells contributes to neointimal formation in mouse injury and atherosclerosis models	Circ Res	13	Article	2016	[97]
8	Vascular smooth muscle cells in atherosclerosis	Circ Res	13	Review	2016	[98]
9	Human gingiva-derived mesenchymal stem cells modulate monocytes/macrophages and alleviate atherosclerosis	Front Immunol	13	Article	2018	[66]
10	Hypoxia-elicited mesenchymal stem cell-derived exosomes facilitates cardiac repair through miR-125b-mediated prevention of cell death in myocardial infarction	Theranostics	12	Article	2018	[99]
11	Role of smooth muscle cells in vascular calcification: implications in atherosclerosis and arterial stiffness	Cardiovasc Res	12	Review	2018	[100]
12	Humoral factors secreted from adipose tissue-derived mesenchymal stem cells ameliorate atherosclerosis in Ldlr-/- mice	Cardiovasc Res	12	Article	2019	[101]
13	Atorvastatin enhances the therapeutic efficacy of mesenchymal stem cells-derived exosomes in acute myocardial infarction via up-regulating long non-coding RNA H19	Cardiovasc Res	12	Article	2020	[102]

Table 6 The top 25 keywords in the field of mesenchymal stem cell therapy for atherosclerosis

Rank	Keywords	Counts	Centrality	Year
1	Mesenchymal stem cells	260	0.11	2004
2	Atherosclerosis	132	0.1	1999
3	Smooth muscle cells	96	0.15	2003
4	Expression	86	0.04	2007
5	Stem cells	72	0.05	2004
6	Progenitor cells	64	0.06	2007
7	Endothelial cells	63	0.05	2005
8	Differentiation	58	0.06	1999
9	In vitro	52	0.05	2004
10	Myocardial infarction	52	0.06	2004
11	Inflammation	52	0.03	2010
12	Bone marrow	51	0.07	2003
13	Endothelial progenitor cells	48	0.05	2004
14	Stromal cells	48	0.1	2004
15	Oxidative stress	45	0.03	2010
16	Proliferation	42	0.04	2005
17	Cardiovascular disease	39	0.07	2004
18	Disease	37	0.01	2009
19	Mechanisms	36	0.05	2007
20	Extracellular vesicles	34	0.02	2016
21	In vivo	32	0.01	2009
22	Vascular calcification	31	0.02	2004
23	Angiogenesis	30	0.08	2003
24	Gene expression	28	0.02	2009
25	Activation	28	0.02	2012