Mechanism of adipose-derived mesenchymal stem cell exosomes in the treatment of heart failure

Table 1 Comparison of left ejection fraction, left ventricular fractional shortening and stroke volume in each group (mean ± SD, %)

Group	n	LVEF	LVFS	SV
Control group	10	83.26 ± 3.41	50.01 ± 2.63	0.27 ± 0.03
HF group	10	40.16 ± 2.37a	28.65 ± 1.84a	0.13 ± 0.02a
ADSCs - exobiology group	10	70.85 ± 2.86a,b	40.27 ± 2.16a,b	0.22 ± 0.03a,b
F value		580.8	229.2	68.64
P value		< 0.0001	< 0.0001	< 0.0001

^aP < 0.05, compared to control group.

^bP < 0.05, compared with heart failure group.

ADSC: Adipose-derived stem cells; HF: Heart failure; LVEF: Left ejection fraction; LVFS: Left ventricular fractional shortening; SV: Stroke volume.

Table 2 Comparison b-type natriuretic peptide of and atrial natriuretic peptide contents in serum of rats in each group (mean ± SD, pg/mL)

Group	n	BNP	ANP
Control group	10	153.62 ± 10.42	123.46 ± 8.11
HF group	10	518.37 ± 15.91a	326.54 ± 11.42a
ADSCs - exobiology group	10	225.43 ± 13.65a,b	151.27 ± 9.34a,b
F value		2044	1283
P value		< 0.0001	< 0.0001

^aP < 0.05, compared to control group.

^bP < 0.05, compared with heart failure group.

ADSC: Adipose-derived stem cells; HF: Heart failure; BNP: B-type natriuretic peptide; ANP: Atrial natriuretic peptide.