Long noncoding RNAs in mesenchymal stromal/stem cells osteogenic differentiation: Implications in osteoarthritis pathogenesis

Table 1 Supplementary information to Figure 1 detailing source and mechanism of activity associated with modified long noncoding RNAs

Upregulated			Downregulated
lncRNAs	Function	Ref.	lncRNAs	Function	Ref.
DANCR	Increased proliferation and chondrogenesis	Wang et al[12], 2020	XIST	Increased inflammation and apoptotic rate	Lian et al[13], 2020
MALAT1	Decreased rate of synovial fibroblast proliferation	Nanus et al[14], 2020	NR024118	Inflammation, apoptosis, and ROS elevation	Mei et al[15], 2019
THRIL	Upregulated inflammatory injury and apoptosis	Liu et al[16], 2019	HULC	Increased inflammation	Chu et al[17], 2019
LINC0051	Results in anti-proliferative actions	Zhang et al[18], 2020	lncRNA-ATB	Increased inflammation	Ying et al[19], 2019
			OIP5-AS1	Decreased cell proliferation and migration, decreased cell anti-inflammatory mediator secretion	Zhi et al[20], 2020

lncRNAs: Long noncoding RNAs.

Table 2 Supplementary information to Figure 2 detailing source and mechanism of activity associated with modified long noncoding RNAs

lncRNAs	Function	Ref.
ARFRP1	Increased apoptosis related proteins	Zhang et al[21], 2020
LOXL-1 AS1	Improved inflammation and proliferation rate	Chen et al[22], 2020
NEAT 1	Increases apoptosis, decreases autophagy, decreases viability	Liu et al[23], 2020
MFI2-AS1	Increases inflammation, ECM degradation, and apoptosis	Luo et al[24], 2020
PART1	Low cell proliferation and increased cellular apoptosis	Zhu et al[25], 2019
TNFSF10	Improves cellular proliferation, anti-apoptotic, and anti-inflammatory actions	Huang et al[26], 2019
XIST	Increases inflammation and apoptosis	Wang et al[27], 2019
FOXD2-AS1	Decreases inflammation, decreases ECM degradation	Wang et al[28], 2019
H19	Decreases proliferation, increases apoptosis, increases inflammation	Hu et al[29], 2019
SNHG16	Decreases proliferation	Fan et al[30], 2020
CTBP1-AS2	Decreases proliferation	Zhang et al[31], 2020
HOTAIR	Increases apoptosis	He et al[32], 2020

ECM: Extracellular matrix; lncRNAs: Long noncoding RNAs.