Copyright ©©The Author(s) 2022.
World J Stem Cells. Jan 26, 2022; 14(1): 54-75
Published online Jan 26, 2022. doi: 10.4252/wjsc.v14.i1.54
Table 1 Human mesenchymal stem cells based clinical trials for solid tumors
Clinical trial ID
Source of MSC
Trial phase
Route of administration
Cell product name (modifying factor)
NCT03298763Umbilical cord MSC (not specified)Adenocarcinoma of lungI/IIIntravenousMSCTRAIL (TRAIL)Recruiting
NCT02530047Bone marrow MSC (not specified)Ovarian cancerIIntraperitonealMSC-INFβ (INF-β)Completed
NCT02068794 ASC (not specified) Ovarian, primary peritoneal or fallopian tube cancerI/IIIntraperitoneal(MV-NIS) Recruiting
NCT02079324 Not specified (not specified)Head and neck cancerIIntratumoralGX-051 (IL-12)Unknown
NCT04657315Not specified (not specified)Recurrent glioblastomaI/IIIntratumoralMSC11FCD (CD)Not yet recruiting
NCT01983709Bone marrow MSC (allogenic)Prostate cancerIIntravenousNot modifiedTerminated
NCT02008539Bone marrow MSC (autologous) Advanced gastrointestinal cancerI/IIInfusionMSC_apceth_101 (HSV-TK)Terminated
2015-000520-29Bone marrow MSC (allogenic)Advanced gastrointestinal adenocarcinomaI/IIIntravenousMSC_apceth_111Prematurely ended
NCT01844661Bone marrow MSC (autologous)Metastatic and refractory solid tumorsI/IIIntravenousCELYVIR (ICOVIR5)Completed
2019-001154-26Bone marrow MSC (allogenic)Relapsed or refractory extracranial solid tumorsIIntravenousAloCELYVIR (ICOVIR-5)Recruiting
NCT04758533Bone marrow MSC (allogenic)Diffuse intrinsic pontine glioma or medulloblastomaI/IIInfusionAloCELYVIR (ICOVIR-5)Not yet recruiting