Regulation of the mesenchymal stem cell fate by interleukin-17: Implications in osteogenic differentiation

Table 1 Interleukin-17 promotes osteogenesis: Summary of the main literature data

Cells	Differentiation effects, differentiation markers, signaling, and transcription factors	Ref.
Primary human BM-MSCs	ALP, mineralization; TRAF6-ACT1-(NOX)1/ROS-MEK-ERK MAPK	Huang et al[97]
Mouse-derived BM-MSCs	Mineralization; WNT10b/RUNX2	He et al[106]
Mouse-derived BM-MSCs	ALP, RUNX2, OCN, and COL-1; AKT, STAT3, and ERK1/2	Liao et al[107]
Human MSC-like primary bone-derived cells	ALP, mineralization; JAK2/STAT3, RUNX2, and C/EBPβ	Jo et al[109]
Human biomimetic human periosteum-derived cell	RUNX2	Shah et al[110]
Mouse mesenchymal precursor C2C12	ERK1/2; RUNX2	Khalmuratova et al[112], and Kocić et al[126]
Human BM-MSCs	BMP2 synergy, mineralization	Croes et al[114]
Human dental pulp-derived MSCs	ALP and mineralization; RUNX2 and osteocalcin	Yu et al[117]
Human exfoliated deciduous teeth-derived MSC	ALP; RUNX2, COL1, OPN, OCN, and OPG	Sebastian et al[118]
Primary mouse progenitor osteoblastic cells	OPG and RANKL	Wang et al[119]
Human BM-MSC	Enhances TNF-α-induced osteogenesis; ALP and mineralization; Schnurri-3	Osta et al[121]
Human fibroblast-like synoviocytes from AR and OA	Enhances TNF-α-induced osteogenesis; RUNX2 and BMP2	Osta et al[125]
Murine calvaria progenitor osteoblastic cells	Mineralization; ALP, OSX, bone sialoprotein, and OPN	Kim et al[128]
Murine calvaria pre-osteoblast cell line MC3T3-E1	ALP and mineralization; RUNX2 and OCN; PI3K/AKT2	Tan et al[130]
Murine calvaria pre-osteoblast cell line MC3T3-E1; Seeded on hydroxyapatite	Synergizes IL-6, ALP; OPG	Sritharan et al[131]

BM: Bone marrow; MSC: Mesenchymal stem/stromal cell; ROS: Reactive oxygen species; OA: Osteoarthritis; TNF-α: tumor necrosis factor α; IL: Interleukin; ALP: Alkaline phosphatase.

Table 2 Interleukin-17 inhibits osteogenesis: Summary of the main literature data

Cells	Differentiation effects, differentiation markers, signaling, and transcription factors	Ref.
Human periodontal ligament stem cells	Reduces mineralization and ALP activity, and OC; Activates ERK1/2 and JNK	Đorđević et al[137]
Human periodontal ligament stem cells	Reduces ALP activity, and RUNX2, SP7, and OCN expression; Inhibits ERK1/2, p38, and JNK signaling	Jian et al[138]
Murine calvaria progenitor osteoblastic cells	Reduces ALP, mineralization, and nodule formation	Kim et al[139]
Murine-derived BM MSC	IκB kinase-NF-κB dependent catenin degradation	Chang et al[141]
Human bone mesenchymal stem cells	Reduces mineralization; Inhibits RUNX2, ALP, and OPN expression; Wnt inhibition by sFRP1 increased expression	Wang et al[142]
Murine calvaria progenitor osteoblastic cells	Reduces mineralization and ALP activity; Inhibits OC expression; Inhibits Wnt signaling by increasing sFRP1 and suppressing sFRP3 expression	Shaw et al[143]
Murine calvaria progenitor osteoblastic cells	Increases miR-214 and RANKL expression	Liu et al[150]

BM: Bone marrow; MSC: Mesenchymal stem/stromal cell; NF-κB: Nuclear factor-κB; ALP: Alkaline phosphatase; OPN: Osteopontin; OC: Osteocalcin.