Copyright ©The Author(s) 2021.
World J Stem Cells. Jan 26, 2021; 13(1): 49-63
Published online Jan 26, 2021. doi: 10.4252/wjsc.v13.i1.49
Table 1 Classification of different types of extracellular vesicles
Apoptotic bodies
Size (nm)20-10050-1000500-2000
MorphologyCup/round shapedVarious shapesHeterogeneous
Sucrose gradient1.13–1.19 g/mL1.04–1.07 g/mL1.16–1.28 g/mL
BiogenesisEndosomesPlasma membranePlasma membrane, endoplasmic reticulum
ContentsNucleic acids, cytoplasmic and membrane protein, major histocompatibility complex, lipidNucleic acids, cytoplasmic and membrane protein, receptor proteins, lipidNuclear fractions, DNA, cell organelles
BiomarkersTetraspanins family, actin, flotillin, Hsc70, Hsp 90, Hsp60 and Hsp20, clathrin, integrinsIntegrins, selectins, flotillin-2, CD40, ligand, metalloproteinaseAnnexin V positivity, phosphatidyl serine