Mechanisms of action of neuropeptide Y on stem cells and its potential applications in orthopaedic disorders

doi:10.4252/wjsc.v12.i9.986

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Sep 26, 2020; 12(9): 986-1000
Published online Sep 26, 2020. doi: 10.4252/wjsc.v12.i9.986

Table 1 Effects of neuropeptide Y receptor-targeted drugs on bone metabolism

Antagonist	Bone phenotype	Administration and subjects
Y1R antagonist BIBP3226[56]	Callus tissue volume ↓, callus bone volume and callus ↓, BV/TV↓	Intraperitoneal injection
Y1R antagonist BIBP3226[56]		Sprague-Dawley rats
Y2R antagonist JNJ-31020028[79]	Vertebral trabecular bone volume ↑, bone mineral density ↑, trabecular thickness ↑; P1NP and CTX biomarkers ↓	Intraperitoneal injection
Y2R antagonist JNJ-31020028[79]		Ovariectomized Mice
Y1R antagonist BIBO3304[80]	Osteoblast activity ↑, cortical and cancellous bone volumes ↑; no adverse effects	Oral administration
Y1R antagonist BIBO3304[80]		Mice

P1NP: Procollagen type 1 N-terminal pro-peptide; CTX: Collagen type I C-telopeptide; BV/TV: Bone volume/total volume.

Citation: Wu JQ, Jiang N, Yu B. Mechanisms of action of neuropeptide Y on stem cells and its potential applications in orthopaedic disorders. World J Stem Cells 2020; 12(9): 986-1000
URL: https://www.wjgnet.com/1948-0210/full/v12/i9/986.htm
DOI: https://dx.doi.org/10.4252/wjsc.v12.i9.986