Copyright ©The Author(s) 2019.
World J Stem Cells. Dec 26, 2019; 11(12): 1020-1044
Published online Dec 26, 2019. doi: 10.4252/wjsc.v11.i12.1020
Table 1 Main differences of differentiation techniques based on iPSCs and direct somatic differentiation technologies
iPSCsDirect somatic differentiation
Reprogramming timeLongNot necessary
Differentiation timeLongBrief
DNA instabilityOccasionalRare
Proliferation of pre-differentiated cellsHigh (iPSCs)Low (e.g., fibroblasts)
Self-renewal of pre-differentiated cellsYes (iPSCs)No (e.g., fibroblasts)
Heterogenicity of the differentiated populationCriticalCritical