Copyright ©The Author(s) 2019.
World J Stem Cells. Nov 26, 2019; 11(11): 904-919
Published online Nov 26, 2019. doi: 10.4252/wjsc.v11.i11.904
Table 1 Table of stem cell classes used to model parasite infections
Stem cell typeParasiteDetailsFuture purpose/possibilitiesRef.
HematopoieticPlasmodium vivaxCluster of differentiation 34+ derived reticulocytesGrowing Plasmodium species that have a reticulocytes preferenceGrosgogeat et al[100]
Leishmania infantumBM HSCs-derived white cells were capable of phagocytosing and supporting promastigote developmentBetter understanding of promastigote development within macrophagesCarvalho-Gontijo et al[101]
NeuronalToxoplasma gondiiFibroblast-derived and CD34+-derived human neuronal-like cells were capable of supporting T. gondii tachyzoite developmentBetter understanding of parasite behaviour and development within human brain cellsPasseri et al[102], Tanaka et al[103]
Liver cellsPlasmodium falciparum, vivax, yoelii, and bergheiHuman iPSC-derived hepatocyte-like cells, expressing important Plasmodium entry receptors CD81 and the SRB1, were permissive to the development many Plasmodium speciesBetter understanding of liver stage infection. Particularly for species such as Plasmodium vivax that can remain dormant in the liver and recrudesce many years laterTeranishi et al[104]