Interferon-gamma and tumor necrosis factor-alpha synergistically enhance the immunosuppressive capacity of human umbilical-cord-derived mesenchymal stem cells by increasing PD-L1 expression

doi:10.4252/wjsc.v15.i8.787

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Aug 26, 2023 (publication date) through Nov 27, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Aug 26, 2023; 15(8): 787-806
Published online Aug 26, 2023. doi: 10.4252/wjsc.v15.i8.787

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Figure 7 Molecular mechanism of interferon-gamma and tumor necrosis factor-alpha synergistically upregulated expression of programmed cell death protein 1 ligand in human umbilical-cord-mesenchymal stem cells to inhibit T cells. IFN-γ: Interferon-gamma; PD-L1: Programmed cell death protein 1 ligand 1; TNF-α: Tumor necrosis factor-alpha; hUC-MSCs: Human umbilical-cord-mesenchymal stem cells; IRF1: Interferon regulatory factor 1.

Citation: Chen Z, Yao MW, Shen ZL, Li SD, Xing W, Guo W, Li Z, Wu XF, Ao LQ, Lu WY, Lian QZ, Xu X, Ao X. Interferon-gamma and tumor necrosis factor-alpha synergistically enhance the immunosuppressive capacity of human umbilical-cord-derived mesenchymal stem cells by increasing PD-L1 expression. World J Stem Cells 2023; 15(8): 787-806
URL: https://www.wjgnet.com/1948-0210/full/v15/i8/787.htm
DOI: https://dx.doi.org/10.4252/wjsc.v15.i8.787