Programmed cell death in stem cell-based therapy: Mechanisms and clinical applications

Figure 6 Role of regulated cell deaths in stem cell-based transplantation and therapeutic pre-strategies to improve the therapy. Stem cell-based therapy has been used in various diseases. A number of stimuli may induce regulated cell deaths (RCDs) in transplanted stem cells (SCs), which results in poorer outcomes. Different signals involved in distinct types of RCDs may provide some targets to improve SC-based transplantation. These therapeutic strategies include preconditioning, pretreatment, gene strategies, and so on. IPC: Ischemic preconditioning; PCD: Programmed cell death; MLKL: Mixed lineage kinase domain like protein; GSDME: Gasdermin E.