Impact of T cells on hematopoietic stem and progenitor cell function: Good guys or bad guys?

doi:10.4252/wjsc.v9.i2.37

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Feb 26, 2017 (publication date) through May 5, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Feb 26, 2017; 9(2): 37-44
Published online Feb 26, 2017. doi: 10.4252/wjsc.v9.i2.37

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Figure 1 Potential mechanisms on how CD8⁺ T cells improve hematopoietic stem and progenitor cells engraftment. The following modes of action have been described or suggested by which donor T cells can support the engraftment of HSPCs upon transplantation: (1) killing of residual host HSPCs; (2) killing of residual host T cells; (3) augmented homing of HSPCs to CXCL12 produced by reticular SC or MSCs; (4) increased HSPC differentiation by IFN-γ-induced production of IL-6 by MSCs. HSPCs: Hematopoietic stem and progenitor cells; SC: Stromal cells; MSCs: Mesenchymal stromal cells; IFN-γ: Interferon-gamma; IL-6: Interleukin-6.

Citation: Geerman S, Nolte MA. Impact of T cells on hematopoietic stem and progenitor cell function: Good guys or bad guys? World J Stem Cells 2017; 9(2): 37-44
URL: https://www.wjgnet.com/1948-0210/full/v9/i2/37.htm
DOI: https://dx.doi.org/10.4252/wjsc.v9.i2.37