Sox2 transcription network acts as a molecular switch to regulate properties of neural stem cells

Figure 1 Diagrams of the Sox2 transcription network and reprogramming. A: Examples from the Sox2 transcription network. Sox2 activates Egfr transcription, and EGFR signaling activates Sox2 transcription. Sox2 also activates Shh transcription, and the Shh signaling downstream factor Gli2 activates Sox2 transcription. Sox2 activates the Nestin and Tlx/Nr2e1 genes but represses NeuroD1 transcription; B: Sox2 and POU factors are assumed to function as a core-partner unit in gene-induced cell reprogramming. iPS: Induced pluripotent stem; iN: Induced neuronal.