Immune regulatory properties of multipotent mesenchymal stromal cells: Where do we stand?

doi:10.4252/wjsc.v3.i1.1

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Jan 26, 2011 (publication date) through Nov 28, 2024

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World Journal of Stem Cells

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1948-0210

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Stem Cells. Jan 26, 2011; 3(1): 1-8
Published online Jan 26, 2011. doi: 10.4252/wjsc.v3.i1.1

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Figure 1 Immune modulation effects of mesenchymal stromal cells on various cells of the immune system. Several soluble factors have been identified to play a major role in immunosuppressive effects of mesenchymal stromal cells (MSC) including prostaglandin E2 (PGE2), transforming growth factor (TGF-β), hepatocyte growth factor (HGF), indoleamine 2,3-dioxygenase (IDO), interleukin-10 (IL-10), nitric oxide, IL-6 and HLA-G. Moreover, cytokines (e.g. IFN-γ), chemokines and Toll-like receptors (TLR) ligands have been shown to modulate/activate immune suppression by MSC.

Citation: Bassi ÊJ, Aita CAM, Câmara NOS. Immune regulatory properties of multipotent mesenchymal stromal cells: Where do we stand? World J Stem Cells 2011; 3(1): 1-8
URL: https://www.wjgnet.com/1948-0210/full/v3/i1/1.htm
DOI: https://dx.doi.org/10.4252/wjsc.v3.i1.1