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©The Author(s) 2024.
世界华人消化杂志. 2024-01-28; 32(1): 71-87
在线出版 2024-01-28. doi: 10.11569/wcjd.v32.i1.71
在线出版 2024-01-28. doi: 10.11569/wcjd.v32.i1.71
作者 | 地区 | 时间 | 样本量 | CLA | LEV | AMX | TET | MNZ | FZD | CLA+MNZ | LEV+MNZ | CLA+LEV | CLA+LEV+MNZ | LEV+MNZ+AMX | CLA+MNZ+AMX |
Gong等[14] | 北京 | 2013-2019 | 138 | 70.29% | |||||||||||
黑龙江 | 25 | 84.00% | |||||||||||||
山东 | 76 | 73.68% | |||||||||||||
湖南 | 38 | 92.11% | |||||||||||||
广西 | 76 | 72.37% | |||||||||||||
云南 | 57 | 78.95% | |||||||||||||
贵州 | 10 | 50.00% | |||||||||||||
青海 | 22 | 86.36% | |||||||||||||
宁夏 | 64 | 78.13% | |||||||||||||
Pan等[15] | 上海 | 1995 | 81 | 4.94% | |||||||||||
广东 | 15 | 6.67% | |||||||||||||
Gao等[16] | 北京 | 2000 | 54 | 14.81% | 1.85% | 38.89% | |||||||||
2001 | 71 | 16.90% | 0 | 36.62% | |||||||||||
2002-2003 | 27 | 22.22% | 0 | 59.26% | |||||||||||
2004-2005 | 27 | 29.63% | 0 | 74.07% | |||||||||||
2006-2007 | 80 | 43.75% | 27.08% | 0 | 2.04% | 81.25% | |||||||||
2008 | 63 | 57.14% | 57.14% | 0 | 0 | 79.37% | |||||||||
2009 | 52 | 65.38% | 63.46% | 0 | 1.92% | 78.85% | |||||||||
Wang等[17] | 北京 | 2007-2009 | 79 | 55.7% | |||||||||||
Ru等[18] | 北京 | 2012 | 70 | 15.71% | 12.86% | 1.43% | 61.43% | ||||||||
2013 | 74 | 16.22% | 21.62% | 1.35% | 59.46% | ||||||||||
2014 | 82 | 20.73% | 18.29% | 0 | 79.27% | ||||||||||
2015 | 77 | 22.08% | 20.78% | 1.30% | 68.83% | ||||||||||
2016 | 83 | 22.89% | 20.48% | 3.61% | 85.54% | ||||||||||
2017 | 72 | 23.61% | 23.61% | 4.17% | 91.67% | ||||||||||
2018 | 81 | 24.69% | 22.22% | 4.94% | 88.89% | ||||||||||
Bai等[19] | 北京 | 2013 | 181 | 30.93% | 3.87% | 61.33% | 26.52% | ||||||||
Li等[20] | 北京 | 2013-2020 | 365 | 85.75% | 68.77% | 2.19% | 0 | 77.53% | 16.71% | ||||||
Tian等[21] | 北京 | 2014-2015、2018-2019 | 160 | 25.63% | 67.50% | 15.00% | 0 | 96.25% | 7.5% | 40.00% | 18.13% | 9.38% | |||
Lok等[22] | 北京 | 2018-2019 | 65 | 52.31% | 38.46% | 26.15% | |||||||||
Gao等[23] | 北京 | 2022发表 | 364 | 65.06% | 7.54% | 20.37% | |||||||||
原素梅等[24] | 山西 | 2011-2012 | 243 | 7.41% | 12.35% | 7.41% | 75.31% | 8.64% | |||||||
Wang等[25] | 辽宁 | 1998-1999 | 23 | 39.1% | 47.8% | 4.3% | 13.0% | 87.0% | |||||||
2002-2004 | 50 | 14.0% | 46.0% | 2.0% | 14.0% | 66.0% | |||||||||
2016-2017 | 27 | 55.6% | 81.5% | 25.9% | 18.5% | 92.6% | |||||||||
Hao等[26] | 辽宁 | 2004发表 | 30 | 23.33% | 0 | 6.67% | 40.00% | ||||||||
郎轶萱等[27] | 吉林 | 2010-2011 | 213 | 17.84% | 30.05% | 2.82% | 52.11% | ||||||||
Wu等[28] | 上海 | 1998-1999 | 153 | 71.90% | 58.82% | 77.78% | |||||||||
Sun等[29] | 上海 | 2000 | 58 | 8.62% | 10.34% | 0 | 0 | 48.28% | 0 | ||||||
2005 | 100 | 9.00% | 24.00% | 0 | 1.00% | 49.00% | 0 | ||||||||
2009 | 135 | 20.74% | 32.59% | 0 | 0 | 42.22% | 0 | ||||||||
Zheng等[30] | 上海 | 2008-2009 | 77 | 20.78% | 0 | 0 | 41.56% | 11.69% | |||||||
Wang等[31] | 上海 | 2019-2020 | 1116 | 27.78% | 31.09% | 0.09% | 0.09% | 79.93% | 0.54% | 11.56% | 15.14% | 1.16% | 12.01% | ||
Liu等[32] | 上海 | 2022发表 | 112 | 16.07% | 34.82% | 0 | 65.18% | ||||||||
Su等[33] | 江苏 | 2006发表 | 46 | 8.70% | |||||||||||
Jiang等[34] | 江苏 | 2017-2019 | 1533 | 47.03% | 33.59% | 2.74% | 0.52% | 80.76% | 0.91% | ||||||
Zhang等[35] | 江苏 | 2018-2019 | 461 | 41.00% | 44.90% | 6.30% | 1.10% | 38.82% | 5.86% | 9.76% | 14.32% | 6.72% | 0.22% | 0.22% | |
Jiang等[36] | 江苏 | 2018-2021 | 2772 | 46.10% | 32.47% | 0.90% | 0.07% | 69.70% | 0.29% | 14.54% | 6.17% | 3.32% | 20.42% | 0.04% | 0.29% |
Su等[37] | 江苏 | 2010-2012 | 34 | 20.6% | 29.4% | 94.1% | |||||||||
浙江 | 17697 | 21.5% | 20.6% | 95.3% | |||||||||||
Ji等[38] | 浙江 | 2009 | 381 | 14.17% | 10.50% | 0 | 100% | 0.03% | 14.17% | 10.50% | 0.52% | 0.52% | |||
2010 | 360 | 25.00% | 16.94% | 0 | 95.56% | 0 | 22.78% | 15.56% | 6.39% | 5.56% | |||||
2011 | 608 | 26.15% | 25.66% | 0 | 93.09% | 0 | 23.85% | 25.66% | 11.84% | 10.36% | |||||
2012 | 1108 | 19.86% | 21.84% | 0 | 96.48% | 0 | 18.77% | 21.48% | 7.40% | 7.22% | |||||
2013 | 3412 | 15.36% | 17.26% | 0 | 94.26% | 0 | 15.36% | 15.74% | 6.80% | 6.01% | |||||
2014 | 3818 | 17.63% | 21.37% | 0.03% | 96.25% | 0 | 16.63% | 20.40% | 7.18% | 6.84% | |||||
Zhang等[39] | 浙江 | 2011-2020 | 94509 | 23.99% | 30.29% | 0.21% | 93.72% | 11.16% | 17.37% | 0.47% | 11.63% | 0.05% | 0.03% | ||
Shao等[40] | 浙江 | 2013-2016 | 2283 | 22.73% | 24.75% | 1.58% | 1.49% | 10.16% | |||||||
Pan等[41] | 浙江 | 2014 | 467 | 26.12% | 28.69% | 0 | 96.79% | 0 | |||||||
Dai等[42] | 浙江 | 2017-2020 | 111 | 32.43% | 35.14% | 0 | 0 | 90.09% | 0 | 30.63% | 33.33% | 20.72% | |||
Wang等[43] | 江西 | 2018-2019 | 124 | 35.48% | 40.32% | 79.84% | |||||||||
Yakoob等[44] | 湖南 | 1996-1999 | 50 | 8.00% | 0 | 50.00% | 6.00% | ||||||||
Hu等[45] | 湖南 | 2023发表 | 104 | 38.50% | 27.88% | 13.46% | 0 | 61.54% | 0 | 27.88% | 20.19% | 15.38% | 13.46% | 3.85% | 6.73% |
孙剑刚等[46] | 湖北 | 2009-2010 | 156 | 12.18% | 14.10% | 0 | 65.38% | 7.05% | |||||||
王松等[47] | 湖北 | 2017-2019 | 460 | 21.74% | 13.04% | 39.13% | 43.48% | ||||||||
Li等[48] | 广东 | 2020 | 54 | 50.00% | 33.33% | 18.52% | 12.96% | 77.78% | 11.11% | 7.41% | 1.85% | 14.81% | |||
Han等[49] | 广东 | 2021-2022 | 88 | 26.14% | 31.82% | 11.36% | |||||||||
Huang等[50] | 广东、福建 | 2017-2020 | 208 | 38.94% | 35.10% | 57.21% | 12.98% | 39.42% | 11.05% | ||||||
Zhao等[51] | 广西 | 2011-2012 | 115 | 31.30% | |||||||||||
Tang等[52] | 西藏 | 2018-2020 | 153 | 27.45% | 31.37% | 15.69% | 0 | 86.27% | 0.65% | 2.61% | 0.65% | ||||
Yang等[53] | 云南 | 2023发表 | 276 | 33.70% | 78.99% | 11.59% | 40.94% | 80.43% | |||||||
吴芳草等[54] | 贵州 | 2016-2018 | 351 | 33.05% | 38.46% | 13.96% | 17.09% | 68.38% | 5.41% | 11.97% | 2.28% | 5.41% | 0.57% | 1.42% | |
周钢等[55] | 重庆 | 2009 | 100 | 4.00% | |||||||||||
2013 | 100 | 12.00% | |||||||||||||
Xu等[56] | 甘肃 | 2018-2020 | 198 | 55.05% | 46.46% | 16.16% | 7.58% | 85.86% | 15.66% | 12.63% | 1.01% | 18.69% | 0.51% | 2.02% | |
Yun等[57] | 甘肃 | 2020-2021 | 112 | 41.96% | 35.71% | 15.18% | 5.36% | 83.04% | 11.61% | 10.71% | 15.18% | 1.79% | 2.68% | ||
Hu等[58] | 宁夏 | 2020-2022 | 1955 | 40.41% | 42.40% | 0.87% | 0.26% | 94.17% | 0.05% | 16.21% | 18.31% | 0.82% | 21.69% | 0.20% | 0.10% |
顾勇等[59] | 陕西 | 2016-2017 | 119 | 10.08% | 14.29% | 1.68% | 28.57% | 5.88% | 4.20% |
地区, 时间 | 耐药率(95%CI) | |||||
华北 | CLA | LEV | AMX | TET | MNZa | FZD |
2006年前 | 18.77%(13.41%-24.81%) | 27.08%(15.28%-41.85%)b | 0.17%(0-1.30%) | 51.24%(33.83%-68.49%) | ||
2007-2010年 | 55.01%(42.42%-67.28%) | 58.27%(51.27%-65.10%) | 0(0-0.49%) | 0.69%(0.02%-2.33%) | 80.01%(74.12%-85.31%) | |
2011-2014年 | 17.49%(10.11%-26.38%) | 14.76%(11.70%-18.11%) | 2.21%(0.31%-5.75%) | 67.90%(59.51%-75.74%) | ||
2015-2018年 | 36.68%(19.18%-56.22%) | 37.00%(21.42%-54.11%) | 4.57%(1.72%-8.70%) | 0(0-0.18%) | 83.96%(75.02%-91.22%) | 8.64%(5.43%-12.91%)b |
2019-2022年 | 65.06%(59.82%-70.03%)b | 7.54%(5.03%-10.78%)b | 20.37%(16.12%-25.17%)b | |||
东北 | CLA | LEV | AMX | TET | MNZ | FZD |
2006年前 | 21.65%(14.27%-30.08%) | 46.57%(35.32%-58.01%) | 7.83%(0-42.50%) | 11.42%(6.03%-18.24%) | ||
2007-2010年 | ||||||
2011-2014年 | 17.84%(12.95%-23.65%)b | 30.05%(23.97%-36.89%)b | 2.82%(1.04%-6.03%)b | |||
2015-2018年 | 55.56%(35.33%-74.52%)b | 81.48%(61.92%-93.70%)b | 25.93%(11.11%-46.28%)b | 18.52%(6.30%-38.08%)b | ||
2019-2022年 | ||||||
华东 | CLAa | LEVa | AMXa | TETa | MNZ | FZD |
2006年前 | 7.41%(4.44%-11.07%) | 16.97%(5.84%-32.37%) | 11.03%(0-70.88%) | 10.27%(0-58.29%) | 59.23%(38.90%- 78.04%) | 59.23%(38.90%-78.04%) |
2007-2010年 | 19.87%(14.84%-25.44%) | 18.99%(8.37%-32.64%) | 0(0-0.45%) | 0(0-0.45%) | 78.29%(36.36%-99.79%) | 78.29%(36.36%-99.79%) |
2011-2014年 | 21.70%(18.17%-25.46%) | 21.40%(18.35%-24.62%) | 0.06%(0-0.17%) | 92.41%(84.26%-97.76%) | 92.41%(84.26%-97.76%) | |
2015-2018年 | 33.59%(24.37%-43.49%) | 34.20%(27.34%-41.41%) | 2.84%(0.76%-6.18%) | 0.63%(0.33%-1.03%) | 75.18%(55.45%-90.56%) | 75.18%(55.45%-90.56%) |
2019-2022年 | 30.40%(18.81%-43.42%) | 32.23%(30.81%-33.66%) | 0.19%(0-0.85%) | 0.07%(0.01%-0.18%) | 76.91%(65.13%-86.86%) | 76.91%(65.13%-86.86%) |
华中 | CLAa | LEV | AMX | TET | MNZ | FZD |
2006年前 | 8.00%(2.22%-19.23%)b | 0(0-7.11%)b | 50.00%(35.53%-64.47%)b | |||
2007-2010年 | 12.18%(7.49%-18.36%)b | 14.10%(9.05%-20.57%)b | 0(0-2.34%)b | 65.38%(57.36%-72.81%)b | 7.05%(3.57%-12.27%)b | |
2011-2014年 | ||||||
2015-2018年 | 21.74%(18.05%-25.79%)b | 13.04%(10.10%-16.47%)b | 39.13%(34.64%-43.76%)b | 70.59%(18.38%-99.97%) | ||
2019-2022年 | 38.50%(29.09%-48.51%)b | 27.88%(19.54%-37.53%)b | 13.46%(7.56%-21.55%)b | 0(0-3.48%)b | 61.54%(51.49%-70.91%)b | 0(0-3.48%)b |
华南 | CLA | LEV | AMX | TET | MNZ | FZD |
2006年前 | 6.67%(0.17%-31.95%)b | |||||
2007-2010年 | ||||||
2011-2014年 | 31.30%(22.98%-40.62%)b | |||||
2015-2018年 | 72.37%(60.91%-82.01%)b | |||||
2019-2022年 | 37.70%(25.40%-50.87%) | 33.99%(29.13%-39.03%) | 37.15%(6.16%-76.10%) | 12.98%(9.19%-17.31%) | 58.92%(21,50%-91.11%) | 11.05%(7.14%-16.13%)b |
西南 | CLA | LEV | AMX | TET | MNZa | FZD |
2006年前 | ||||||
2007-2010年 | 4.00%(1.10%-9.93%)b | |||||
2011-2014年 | 12.00%(6.36%-20.02%)b | |||||
2015-2018年 | 33.05%(28.15%-38.24%)b | 38.46%(33.35%-43.77%)b | 13.96%(10.51%-18.03%)b | 17.09%(13.31%-21.45%)b | 69.40%(64.91%-73.73%) | |
2019-2022年 | 31.02%(25.13%-37.24%) | 55.97%(12.10%-94.56%) | 12.99%(9.98%-16.34%) | 11.61%(0-73.33%) | 83.11%(77.01%-88.44%) | 0.65%(0.02%-3.59%)b |
西北 | CLAa | LEVa | AMX | TET | MNZa | FZD |
2006年前 | ||||||
2007-2010年 | ||||||
2011-2014年 | ||||||
2015-2018年 | 10.08%(5.32%-16.95%)b | 14.29%(8.55%-21.88%)b | 1.68%(0.20%-5.94%)b | 55.08%(8.79%-96.08%) | ||
2019-2022年 | 45.59%(36.50%-54.83%) | 42.42%(40.39%-44.46%) | 8.68%(0.82%-23.62%) | 3.32%(0.17%-10.21%) | 88.59%(80.59%-94.67%) | 0.05%(0-0.28%)b |
CLA+MNZ | LEV+MNZ | CLA+LEV | CLA+LEV+MNZ | LEV+MNZ+AMX | CLA+MNZ+AMX | |
全国 | 14.05%(10.70%-17.77%) | 15.12%(11.53%-19.10%) | 5.16%(2.87%-8.06%) | 10.36%(7.45%-13.69%) | 0.92%(0.12%-2.44%) | 0.85%(0.20%-1.92%) |
华北 | 16.16%(6.95%-28.28%) | 40.00%(32.35%-48.03%)a | 26.15%(16.03%-38.54%)a | 18.13%(12.49%-24.98%)a | 9.38%(5.34%-14.99%)a | |
华东 | 15.76%(12.38%-19.47%) | 16.55%(12.48%-21.06%) | 5.32%(2.79%-8.60%) | 8.81%(5.51%-12.80%) | 0.05%(0.04%-0.07%) | 0.13%(0.01%-0.39%) |
华中 | 15.60%(1.07%-42.35%) | 20.19%(12.96%-29.19%)a | 15.38%(9.06%-23.78%)a | 13.46%(7.56%-21.55%)a | 3.85%(1.06%-9.56%)a | 6.73%(2.75%-13.38%)a |
华南 | 11.11%(4.19%-22.63%)a | 7.41%(2.06%-17.89%)a | 5.86%(0.17%-18.72%) | 14.81%(6.62%-27.12%)a | ||
西南 | 2.57%(0.01%-9.40%) | 7.60%(1.64%-17.37%) | 1.50%(0.30%-3.60%) | 4.14%(1.81%-7.36%) | 0.57%(0.07%-2.04%)a | 1.16%(0.41%-2.28%) |
西北 | 12.47%(7.99%-17.78%) | 11.28%(5.89%-18.13%) | 0.84%(0.49%-1.26%) | 21.08%(19.42%-22.78%) | 0.27%(0.10%-0.52%) | 0.85%(0.20%-1.92%) |
效应量 | P值 |
华东CLA耐药率 | 0.6534 |
全国CLA耐药率 | 0.7898 |
华东LEV耐药率 | 0.5459 |
全国LEV耐药率 | 0.5913 |
华东AMX耐药率 | 0.0994 |
全国AMX耐药率 | 0.3223 |
全国TET耐药率 | 0.0790 |
华东MNZ耐药率 | 0.1072 |
华东FZD耐药率 | 0.1611 |
全国CLA+MNZ耐药率 | 0.1030 |
全国LEV+MNZ耐药率 | 0.3989 |
全国CLA+LEV耐药率 | 0.2483 |
全国CLA+LEV+MNZ耐药率 | 0.7529 |
引文著录: 王佳悦, 周显祝, 王婵娟, 许诗涵, 朱惠云, 杜奕奇. 中国不同地区幽门螺杆菌耐药状况的荟萃分析. 世界华人消化杂志 2024; 32(1): 71-87