基础研究
Copyright ©The Author(s) 2022.
世界华人消化杂志. 2022-02-28; 30(4): 182-190
在线出版 2022-02-28. doi: 10.11569/wcjd.v30.i4.182
表1 连翘苷对胃癌HGC-27细胞增殖、迁移、侵袭及炎症因子表达的影响(mean±SD, n = 3)
分组抑制率/%细胞数/个
pg/mL
E-cadherin (97kDa)N-cadherin (125kDa)
克隆迁移侵袭TNF-αIL-6
对照组0.00±0.00113.00±8.83174.33±9.98143.00±6.68269.57±16.67352.17±29.150.22±0.020.57±0.06
连翘苷低剂量组18.39±1.67a88.67±4.50a148.33±7.59a115.67±4.11a211.12±10.37a280.73±17.75a0.37±0.04a0.43±0.03a
连翘苷中剂量组36.29±4.39ab59.67±1.70ab106.33±6.94ab86.33±2.62ab146.95±10.01ab214.76±18.47ab0.57±0.06ab0.27±0.04ab
连翘苷高剂量组61.62±4.00abc41.00±2.45abc73.00±3.74abc54.00±2.94abc95.15±7.04abc124.96±11.62abc0.82±0.07abc0.15±0.01abc
F217.62571.444109.944228.358129.15968.4377.14365.226
P00000000
表2 连翘苷对HGC-27中LINC00342表达的检测(mean±SD, n = 3)
分组LINC00342
对照组1.00±0.00
连翘苷低剂量组0.77±0.05a
连翘苷中剂量组0.47±0.03ab
连翘苷高剂量组0.24±0.02abc
F351.368
P0.000
表3 敲减LINC00342对HGC-27细胞增殖、迁移、侵袭及炎症因子表达的影响(mean±SD, n = 3)
分组抑制率/%细胞数/个
pg/mL
E-cadherinN-cadherin
克隆迁移侵袭TNF-αIL-6
si-NC组0.00±0.00112.33±5.79174.00±7.87142.33±6.94264.51±18.17342.49±29.260.23±0.020.58±0.04
si-LINC0034组54.49±3.09a52.00±2.83a75.00±3.56a63.00±2.45a119.54±11.23a143.82±9.05a0.71±0.05a0.12±0.02a
t30.54416.21419.85218.67011.75511.23515.43817.816
P0.0000.0000.0000.0000.0000.0000.0000.000
表4 过表达LINC00342逆转连翘苷对HGC-27细胞增殖、迁移、侵袭及炎症因子表达的影响(mean±SD, n = 3)
分组抑制率/%细胞数/个
pg/mL
E-cadherinN-cadherin
克隆迁移侵袭TNF-αIL-6
对照组0.00±0.00112.67±9.53173.33±10.62143.00±5.10271.23±24.63354.88±29.220.22±0.020.58±0.07
连翘苷组60.68±5.54a40.67±3.30a72.67±5.44a53.67±2.62a97.50±7.71a124.16±7.24a0.81±0.06a0.15±0.02a
连翘苷+pcDNA -LINC00342组15.06±1.21b97.00±4.55b156.67±10.66b128.67±4.50b230.23±13.56b314.21±20.50b0.28±0.04b0.50±0.04b
F279.424105.413102.334389.93987.399102.910169.44668.217
P0.0000.0000.0000.0000.0000.0000.0000.000

引文著录: 李绍智, 练维生. 连翘苷调控LINC00342影响胃癌细胞增殖、迁移和侵袭及炎症因子表达的实验研究. 世界华人消化杂志 2022; 30(4): 182-190