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©The Author(s) 2018.
世界华人消化杂志. 2018-07-08; 26(19): 1176-1185
在线出版 2018-07-08. doi: 10.11569/wcjd.v26.i19.1176
在线出版 2018-07-08. doi: 10.11569/wcjd.v26.i19.1176
表1 有无POF的AP病人的人口统计学和生化指标的比较
变量 | POF组 (n = 32) | 无POF组 (n = 120) | t (χ2) | P |
年龄 | 50.28 ± 14.13 | 46.88 ± 14.43 | -1.191 | 0.2351 |
性别 (男/女) | 24/8 (75.0%) | 68/52 (56.7%) | 3.554 | 0.0592 |
病因 | ||||
高脂血症 | 12/65 (18.5%) | 53/65 (81.5%) | 0.47 | 0.9252 |
胆源性 | 13/57 (22.8%) | 44/57 (77.2%) | ||
酗酒 | 1/4 (25.0%) | 3/4 (75%) | ||
不明原因 | 6/26 (23.1%) | 20/26 (76.9%) | ||
ALT (U/L) | 97.39 ± 169.14 | 74.56 ± 127.42 | 0.822 | 0.4121 |
AST (U/L) | 73.57 ± 92.08 | 67.04 ± 118.20 | 0.281 | 0.7791 |
总胆 (mg/dL) | 29.08 ± 34.31 | 16.25 ± 11.81 | 2.05 | 0.0491 |
直胆 (mg/dL) | 15.58 ± 27.91 | 6.04 ± 7.75 | 1.914 | 0.0651 |
LDH (U/L) | 283.87 ± 82.20 | 239.43 ± 92.45 | 2.369 | 0.0191 |
淀粉酶 (U/L) | 590.18 ± 572.56 | 635.85 ± 1010.81 | -0.229 | 0.8191 |
血糖 (mg/dL) | 11.26 ± 4.77 | 8.17 ± 3.99 | 3.714 | 0.0001 |
BUN (mg/dL) | 4.70 ± 2.24 | 6.74 ± 12.95 | -0.884 | 0.3781 |
Cr (mg/dL) | 68.19 ± 27.43 | 61.87 ± 23.81 | 1.287 | 0.2001 |
白蛋白 (g/L) | 39.67 ± 9.16 | 44.73 ± 7.60 | -3.188 | 0.0021 |
钙 (mg/dL) | 2.54 ± 1.54 | 2.29 ± 0.40 | 0.86 | 0.3971 |
钠 (mmol/L) | 137.31 ± 5.22 | 138.19 ± 4.78 | -0.877 | 0.3821 |
CRP (mg/L) | 76.03 ± 88.97 | 46.70 ± 75.41 | 1.874 | 0.0631 |
表2 有无PN的AP病人的人口统计学和生化指标的比较
变量 | PN组 (n = 44) | 无PN组 (n = 108) | t (χ2) | P |
年龄 (岁) | 47.64 ± 13.26 | 47.57 ± 14.89 | 0.024 | 0.9811 |
性别 (男/女) | 26/18(59.1%) | 66/42(61.1%) | 0.053 | 0.8172 |
病因 | 0.660 | 0.8822 | ||
高脂血症 | 19/65(29.2%) | 46/65(70.8%) | ||
胆源性 | 18/57(31.6%) | 39/57(68.4%) | ||
酗酒 | 1/4(25.0%) | 3/4(75.0%) | ||
不明原因 | 6/26(23.1%) | 20/26(76.9%) | ||
ALT (U/L) | 84.78 ± 152.65 | 77.17 ± 130.67 | 0.305 | 0.7611 |
AST (U/L) | 69.61 ± 98.77 | 67.87 ± 118.98 | 0.084 | 0.9331 |
TB (μmol/L) | 26.82 ± 31.68 | 15.70 ± 9.54 | 2.260 | 0.0291 |
DB (μmol/L) | 14.17 ± 25.73 | 5.61 ± 5.57 | 2.160 | 0.0361 |
LDH (U/L) | 274.62 ± 92.29 | 237.30 ± 90.06 | 2.272 | 0.0251 |
AMY (U/L) | 750.33 ± 705.14 | 579.00 ± 1005.02 | 0.938 | 0.3501 |
GLu (mmol/L) | 10.13 ± 5.19 | 8.29 ± 3.83 | 2.406 | 0.0171 |
BUN (mmol/L) | 4.90 ± 3.22 | 6.87 ± 13.52 | -0.941 | 0.3481 |
Cr (μmol/L) | 64.85 ± 32.33 | 62.54 ± 20.81 | 0.519 | 0.6051 |
ALB (g/L) | 41.71 ± 8.75 | 44.45 ± 7.85 | -1.877 | 0.0621 |
Ca2+ (mmol/L) | 2.32 ± 0.69 | 2.35 ± 0.81 | -0.233 | 0.8161 |
Na+ (mmol/L) | 136.98 ± 6.18 | 138.45 ± 4.16 | -1.684 | 0.0941 |
CRP (mg/L) | 64.03 ± 94.06 | 48.52 ± 72.23 | 1.084 | 0.2801 |
表3 入院后第1、2、3和7天, 有无POF的AP病人中FRMs的变化
FM | POF组 | 无POF组 | Z (t) | P |
FM1 | 5.12 (5.00, 13.25) | 5.49 (5.00, 8.02) | -0.290 | 0.7711 |
FM2 | 6.80 (5.00, 14.35) | 5.22 (5.00, 6.98) | -1.854 | 0.0641 |
FM3 | 5.90 (5.00, 7.21) | 5.17 (5.00, 7.60) | -0.643 | 0.5201 |
FM7 | 6.90 (5.00, 12.11) | 5.96 (5.00, 8.31) | -0.926 | 0.3541 |
D-D1 | 1.41 (0.66, 4.00) | 0.67 (0.39, 1.15) | -3.247 | 0.0011 |
D-D2 | 2.79 (1.39, 4.00) | 1.43 (0.69, 2.48) | -2.911 | 0.0041 |
D-D3 | 4.00 (2.51, 4.00) | 1.38 (0.82, 2.75) | -4.353 | 0.0001 |
D-D7 | 4.00 (2.01, 4.00) | 1.90 (0.81, 3.36) | -3.060 | 0.0021 |
FDP1 | 7.26 (3.01, 25.84) | 3.07 (1.73, 5.46) | -3.497 | 0.0001 |
FDP2 | 16.95 (5.20, 27.15) | 4.49 (3.23, 8.82) | -3.158 | 0.0021 |
FDP3 | 22.15 (8.66, 27.78) | 6.26 (3.47, 13.48) | -4.223 | 0.0001 |
FDP7 | 15.93 (8.33, 31.63) | 5.38 (2.91, 11.40) | -3.753 | 0.0001 |
FIB1 | 3.91 ± 1.95 | 3.70 ± 1.33 | 0.564 | 0.5762 |
FIB2 | 5.45 ± 2.38 | 4.72 ± 1.45 | 1.211 | 0.2332 |
FIB3 | 5.57 ± 1.93 | 4.96 ± 1.98 | 1.426 | 0.1572 |
FIB7 | 5.04 ± 1.69 | 4.29 ± 1.27 | 2.300 | 0.0242 |
表4 入院后第1、2、3和7天, 有无PN的AP中FRMs的变化
FM | PN组 (44) | 无PN组 (108) | Z (t) | P |
FM1 | 6.82 (5.00, 18.09) | 5.00 (5.00, 7.69) | -2.026 | 0.0431 |
FM2 | 6.47 (5.00, 12.58) | 5.00 (5.00, 6.98) | -2.650 | 0.0081 |
FM3 | 7.11 (5.00, 13.09) | 5.00 (5.00, 6.93) | -3.277 | 0.0011 |
FM7 | 7.50 (5.91, 10.68) | 5.52 (5.00, 7.60) | -3.030 | 0.0041 |
D-D1 | 0.97 (0.63, 1.83) | 0.66 (0.39, 1.30) | -2.276 | 0.0231 |
D-D2 | 1.79 (1.28, 4.00) | 1.42 (0.73, 3.56) | -1.163 | 0.0451 |
D-D3 | 4.00 (2.66, 4.00) | 1.30 (0.75, 2.49) | -5.676 | 0.0001 |
D-D7 | 4.00 (2.66, 4.00) | 1.57 (0.88, 2.93) | -4.115 | 0.0001 |
FDP1 | 3.73 (2.56, 8.41) | 3.14 (1.72, 6.17) | -1.803 | 0.0711 |
FDP2 | 9.38 (4.06, 22.24) | 4.68 (3.11, 9.85) | -2.324 | 0.0211 |
FDP3 | 20.69 (10.14, 27.65) | 5.74 (3.31, 11.26) | -5.392 | 0.0001 |
FDP7 | 17.34 (7.57, 30.90) | 4.81 (2.79, 8.42) | -5.207 | 0.0001 |
FIB1 | 3.63 ± 1.62 | 3.80 ± 1.43 | -0.649 | 0.5172 |
FIB2 | 4.82 ± 1.98 | 5.02 ± 1.6 | -0.353 | 0.7262 |
FIB3 | 5.46 ± 2.16 | 4.95 ± 1.88 | 1.220 | 0.2272 |
FIB7 | 4.59 ± 1.64 | 4.42 ± 1.32 | 0.545 | 0.5872 |
表5 入院后第1、2和3天FRMs其他生化指标对AP伴POF的预测
Cut-offvalue | AUC | 95%CI | Sn (%) | Sp (%) | PPV (%) | NPV (%) | Z | P | |
D-D1 | 1.18 | 0.693 | (0.611, 0.767) | 60.00 | 76.99 | 40.91 | 87.88 | 3.247 | 0.0012 |
FDP1 | 4.63 | 0.711 | (0.629, 0.784) | 65.52 | 70.80 | 36.53 | 88.89 | 3.725 | 0.0002 |
LDH1 | 218.72 | 0.672 | (0.590, 0.747) | 82.76 | 49.58 | 28.57 | 92.19 | 3.528 | 0.0004 |
GLU1 | 8.6 | 0.720 | (0.640, 0.790) | 71.87 | 75.21 | 42.24 | 90.72 | 3.913 | 0.0001 |
A1 | 40.58 | 0.661 | (0.579, 0.737) | 53.13 | 81.90 | 44.74 | 86.37 | 2.725 | 0.0064 |
CRP1 | 84 | 0.615 | (0.532, 0.694) | 34.38 | 86.32 | 40.74 | 82.78 | 2.022 | 0.0431 |
D-D2 | 2.07 | 0.731 | (0.604, 0.836) | 73.68 | 74.42 | 56.01 | 86.48 | 3.357 | 0.0008 |
FDP2 | 10.69 | 0.755 | (0.632, 0.854) | 61.11 | 82.61 | 57.89 | 84.21 | 3.881 | 0.0001 |
AT-Ⅲ2 | 55 | 0.584 | (0.498, 0.666) | 25.00 | 98.25 | 77.82 | 84.21 | 1.330 | 0.1836 |
LDH2 | 261.59 | 0.761 | (0.684, 0.828) | 54.84 | 87.93 | 54.84 | 87.93 | 5.156 | <0.0001 |
CRP2 | 74.05 | 0.718 | (0.684, 0.828) | 83.33 | 51.72 | 30.86 | 92.30 | 4.446 | <0.0001 |
D-D3 | 1.94 | 0.776 | (0.687, 0.849) | 88.90 | 61.90 | 42.85 | 94.55 | 5.651 | <0.0001 |
FDP3 | 15.51 | 0.769 | (0.682, 0.843) | 66.67 | 80.68 | 51.43 | 88.75 | 4.997 | <0.0001 |
AT-Ⅲ3 | 95 | 0.664 | (0.581, 0.740) | 93.33 | 37.39 | 28.00 | 95.55 | 2.930 | 0.0034 |
LDH3 | 233.64 | 0.731 | (0.651, 0.801) | 55.17 | 82.91 | 44.45 | 88.18 | 4.363 | <0.0001 |
CRP3 | 203 | 0.777 | (0.506, 0.680) | 45.16 | 95.65 | 73.67 | 86.62 | 6.151 | <0.0001 |
表6 入院后第1、2、3和7天FRMs及其他生化指标对PN的预测
Cut-offvalue | AUC | 95%CI | Sn (%) | Sp (%) | PPV (%) | NPV (%) | Z | P | |
FM1 | 5.58 | 0.595 | (0.506, 0.680) | 62.50 | 58.70 | 39.68 | 78.26 | 1.810 | 0.0703 |
D-D1 | 0.86 | 0.622 | (0.537, 0.702) | 63.41 | 62.75 | 40.62 | 81.01 | 2.354 | 0.0186 |
LDH1 | 240.66 | 0.635 | (0.552, 0.712) | 66.44 | 64.76 | 43.93 | 82.93 | 2.620 | 0.0088 |
GLU1 | 8.2 | 0.629 | (0.546, 0.706) | 56.82 | 68.57 | 40.68 | 79.42 | 2.483 | 0.0130 |
ALB1 | 43.15 | 0.607 | (0.523,0.686) | 61.36 | 62.50 | 40.91 | 79.27 | 2.064 | 0.0390 |
CRP1 | 78 | 0.545 | (0.462, 0.627) | 27.91 | 83.96 | 41.38 | 74.17 | 0.854 | 0.3931 |
FM2 | 5.94 | 0.639 | (0.549, 0.723) | 60.98 | 69.41 | 49.02 | 78.67 | 2.711 | 0.0067 |
D-D2 | 1.42 | 0.590 | (0.458, 0.713) | 76.19 | 51.22 | 44.44 | 80.77 | 1.212 | 0.2256 |
FDP2 | 6.23 | 0.676 | (0.548, 0.788) | 68.18 | 66.67 | 51.73 | 80.00 | 2.489 | 0.0128 |
LDH2 | 278.31 | 0.633 | (0.550, 0.711) | 31.82 | 91.26 | 60.86 | 75.81 | 2.569 | 0.0102 |
CRP2 | 102 | 0.614 | (0.530, 0.694) | 53.49 | 68.93 | 41.81 | 78.02 | 2.186 | 0.0288 |
FM3 | 5.87 | 0.683 | (0.590, 0.766) | 65.71 | 67.50 | 46.93 | 81.82 | 3.339 | 0.0008 |
D-D3 | 2.63 | 0.832 | (0.749, 0.896) | 77.14 | 81.58 | 65.85 | 88.57 | 8.422 | <0.0001 |
FDP3 | 14.09 | 0.814 | (0.731, 0.881) | 69.44 | 83.54 | 65.78 | 85.71 | 7.502 | <0.0001 |
AT-Ⅲ3 | 81 | 0.635 | (0.551, 0.713) | 59.09 | 68.32 | 44.82 | 79.31 | 2.613 | 0.0090 |
LDH3 | 160.89 | 0.639 | (0.556, 0.717) | 88.10 | 37.50 | 36.27 | 88.64 | 2.754 | 0.0059 |
CRP3 | 105.03 | 0.706 | (0.625, 0.779) | 65.91 | 76.47 | 54.72 | 83.37 | 4.072 | <0.0001 |
FM7 | 5.87 | 0.698 | (0.596, 0.788) | 88.46 | 52.17 | 41.07 | 92.31 | 3.574 | 0.0004 |
D-D7 | 3.87 | 0.761 | (0.664, 0.841) | 65.52 | 86.96 | 67.86 | 85.72 | 4.371 | <0.0001 |
FDP7 | 8.79 | 0.825 | (0.735, 0.894) | 75.00 | 82.09 | 66.66 | 87.30 | 6.610 | <0.0001 |
AT-Ⅲ7 | 94 | 0.639 | (0.552, 0.720) | 78.05 | 45.26 | 38.10 | 82.69 | 2.679 | 0.0074 |
LDH7 | 177.12 | 0.661 | (0.575, 0.740) | 78.57 | 50.00 | 41.25 | 83.93 | 3.182 | 0.0015 |
CRP7 | 42 | 0.708 | (0.624, 0.783) | 60.98 | 81.91 | 59.52 | 82.80 | 3.934 | 0.0001 |
引文著录: 雷静静, 周力, 熊灿, 刘琦, 邓宛航. 急性胰腺炎血浆纤维蛋白相关标志物的动态变化及临床意义. 世界华人消化杂志 2018; 26(19): 1176-1185