溃疡性结肠炎患者血清降钙素原检测的临床价值

表1 31例溃疡性结肠炎患者临床特征

特征	UC
n	31
性别(n, 男/女)	19/12
平均年龄(岁, 范围)	41.2(16-64)
平均病程(mo, 范围)	59.7(1 mo-23年)
病变范围(n)
E1(直肠)	1
E2(左半结肠)	10
E3(广泛结肠)	20
治疗[n(%)]
5-氨基水杨酸	11(35.5)
激素+免疫抑制剂	2(6.5)
激素+5-氨基水杨酸	16(51.6)
抗-TNFα抗体	2(6.5)
手术1	11(35.5)

¹手术病例为其他药物治疗效果欠佳后进行. UC: 溃疡性结肠炎; TNFα: 肿瘤坏死因子α.

表2 炎症标志物预测重度溃疡性结肠炎的检验效能 (%)

炎症标志物	敏感性(95%CI)	特异性(95%CI)	阳性预测值(95%CI)	阴性预测值(95%CI)
PCT(μg/L)
≥0.050	100.00(67.86-100.00)	50.00(27.85-72.15)	52.381(30.34-73.61)	100.00(65.55-100.00)
≥0.075	100.00(67.86-100.00)	80.00(55.73-93.39)	73.33(44.83-91.09)	100.00(75.93-100.00)
≥0.100	90.91(57.12-99.52)	80.00(55.73-93.39)	71.43(42.00-90.42)	94.12(69.24-99.69)
≥0.125	72.73(39.32-92.67)	80.00(55.73-93.39)	66.67(35.44-88.73)	84.21(59.51-95.83)
≥0.150	63.64(31.61-87.63)	85.00(61.14-96.04)	70.00(35.37-91.91)	80.95(57.42-93.71)
≥0.200	45.45(18.14-75.44)	85.00(61.14-96.04)	62.50(25.89-89.76)	73.91(51.31-88.92)
≥0.300	36.37(12.37-68.39)	95.00(73.06-99.74)	80.00(29.88-98.95)	73.08(51.95-87.65)
≥0.400	36.37(12.37-68.39)	100.00(79.95-100.00)	100.00(39.58-100.00)	74.07(53.41-88.13)
CRP(mg/L)
≥8	100.00(67.86-100.00)	45.00(23.83-67.95)	50.00(28.80-71.20)	100.00(62.88-100.00)
≥15	100.00(67.86-100.00)	70.00(45.67-87.16)	64.71(38.62-84.74)	100.00(73.24-100.00)
≥20	72.73(39.32-92.67)	70.00(45.67-87.16)	57.14(29.65-81.19)	82.35(55.80-95.33)
≥30	72.73(39.32-92.67)	80.00(55.73-93.39)	66.67(35.44-88.73)	84.21(59.51-95.83)
≥40	54.55(24.56-81.86)	80.00(55.73-93.39)	60.00(27.37-86.31)	76.19(52.45-90.88)
≥60	36.36(12.37-68.39)	85.00(61.14-96.04)	57.14(20.24-88.19)	70.83(48.75-86.56)
ESR(mm/h)
≥10	100.00(67.86-100.00)	36.84(17.23-61.37)	47.26(27.42-68.92)	100.00(56.09-100.00)
≥20	81.82(47.76-96.79)	47.37(25.21-70.50)	47.37(25.21-70.50)	81.82(47.76-96.79)
≥30	63.64(31.61-87.63)	68.42(43.50-86.44)	53.85(26.12-79.60)	76.47(49.76-92.18)
≥40	36.36(12.37-68.39)	84.21(59.51-95.83)	57.14(20.24-88.19)	69.57(46.99-85.94)
≥50	27.27(7.33-60.68)	94.74(71.89-99.72)	75.00(21.94-98.68)	69.23(48.10-84.91)

CI: 可信区间; PCT: 降钙素原; CRP: C-反应蛋白; ESR: 血沉.