抑制JAK/STAT3信号通路对重症急性胰腺炎肾损伤的保护作用

表1 各组大鼠血清中AMY和肾功能指标结果比较 (mean±SD, n = 8)

分组	AMY(U/L)	Cr(μmol/L)	BUN(mmol/L)
对照组	656.94±53.69	37.41±1.71	3.45±0.31
SAP造模组
6 h	2542.25±287.511bd	57.44±1.19bd	9.52±0.61bd
12 h	3257.69±237.991bd	68.37±1.96bd	14.66±0.84bd
18 h	4091.13±368.481bd	91.78±2.40bd	19.53±1.07bd
AG490治疗组
6 h	1614.30±77.16bd	42.41±1.63bd	7.91±0.45bd
12 h	2634.48±97.63bd	65.99±3.15bd	11.24±0.53bd
18 h	3246.94±133.57bd	74.58±1.95bd	13.61±0.75bd

^bP<0.01 vs 对照组;

^dP<0.01 vs SAP组.

表2 各组大鼠血清中IL-6和TNF-α含量比较 (pg/mL, mean±SD, n = 8)

分组	IL-6	TNF-α
对照组	55.56±4.81	87.09±5.45
SAP造模组
6 h	322.24±16.93bd	288.12±12.42bd
12 h	379.02±10.87bd	327.83±16.70bd
18 h	434.55±20.91bd	420.78±16.27bd
AG490 治疗组
6 h	139.61±9.62bd	142.93±10.03bd
12 h	249.30±18.74bd	271.74±7.99bd
18 h	331.02±13.89bd	337.29±10.04bd

^bP<0.01 vs 对照组;

^dP<0.01 vs SAP组.