钴原卟啉对大鼠急性胰腺炎的抑制作用及其机制

表1 各组大鼠不同时间点胰腺组织病理评分 (n = 10, mean±SD, 分)

分组	6 h	12 h	24 h
SO组	0.00±0.00	0.00±0.00	0.00±0.00
AP组	5.40±0.37b	7.50±0.53b	9.13±1.02b
CoPP组	4.50±0.42bd	6.10±1.06bd	9.42±0.87b

^bP<0.01 vs SO组;

^dP<0.01 vs AP组.

表2 各组大鼠不同时间点血清淀粉酶的比较 (n = 10, mean±SD, U/L)

分组	6 h	12 h	24 h
SO组	766.7±112.77	881.5±145.78	819.1±177.81
AP组	9 110.8±1 014.84b	8 385.0±1 136.76b	8 991.7±911.54b
CoPP组	7 413.2±684.92bd	6 314.4±472.35bd	8 298.0±1 015.67b

^bP<0.01 vs SO组;

^dP<0.01 vs AP组.

表3 各组大鼠术后不同时间点血清中TNF-α、IL-6水平的比较 (n = 10, mean±SD, ng/L)

分组	TNF-α			IL-6
	6 h	12 h	24 h	6 h	12 h	24 h
SO组	25.89 ± 1.21	26.14 ± 0.99	25.71 ± 0.84	84.49 ± 13.14	92.81 ± 11.08	89.51 ± 14.73
AP组	94.42 ± 10.73b	116.05 ± 21.87b	157.84 ± 19.72b	489.07 ± 54.13b	520.72 ± 48.75b	552.92 ± 72.96b
CoPP组	69.11 ± 7.18bd	78.60 ± 8.75bd	142.09 ± 22.61b	350.14 ± 41.24bd	438.97 ± 51.29bd	511.03 ± 57.76b

^bP<0.01 vs SO组;

^dP<0.01 vs AP组.

表4 各组大鼠术后不同时间点PBMC及胰腺组织中HO-1 mRNA相对表达量的比较 (n = 10, mean±SD)

分组	PBMC			胰腺组织
	6 h	12 h	24 h	6 h	12 h	24 h
SO组	0.841 ± 0.169	0.737 ± 0.075	0.780 ± 0.105	5.715 ± 1.002	5.464 ± 0.907	5.604 ± 0.988
AP组	1.773 ± 0.278b	2.330 ± 0.281b	2.795 ± 0.282b	9.493 ± 1.341b	13.740 ± 1.936b	16.436 ± 2.219b
CoPP组	2.614 ± 0.213bc	3.531 ± 0.364bd	5.174 ± 0.631bd	15.538 ± 2.829bc	21.407 ± 2.712bc	28.902 ± 3.791bd

^bP<0.01 vs SO组;

^cP<0.05,

^dP<0.01 vs AP组.