白花蛇舌草总黄酮抑制人肝癌细胞的靶基因调控

表1 FHD处理人肝癌细胞SMMC-7721后表达显著下调至正常的靶基因

Accession	Gene description	Ratio
		C/N	T/N
Hs.1722	Interleukin 1 alpha	5.0	1.0
Hs.227777	Protein tyrosine phosphatase type IVA, member 1	4.3	1.0
Hs.284244	Fibroblast growth factor 2 (basic)	3.7	1.0
Hs.79070	V-myc avian myelocytomatosis viral oncogene homolog	3.4	1.0
Hs.858	V-rel avian reticuloendotheliosis viral oncogene homolog B (nuclear factor of kappa light polypeptide gene enhancer in B-cells 3)	3.1	1.0
Hs.21704	Transcription factor 12 (HTF4, helix-loop-helix transcription factors 4)	3.1	1.0
Hs.204354	Ras homolog gene family, member B	2.9	1.0
Hs.23016	G protein-coupled receptor	2.6	1.0
Hs.227817	Bcl2-related protein A1	2.3	1.0
Hs.1516	Insulin-like growth factor-binding protein 4	2.22	1.0
Hs.81170	Pim-1 oncogene	2.1	1.0
Hs.25647	V-fos FBJ murine osteosarcoma viral oncogene homolog	2.1	1.0
Hs.285754	Met proto-oncogene (hepatocyte growth factor receptor)	2.1	1.0
Hs.154970	Transcription factor CP2	2.0	1.0
Hs.239176	Insulin-like growth factor 1 receptor	2.0	1.0

C/N: 肝癌细胞(C)基因表达丰度值/肝正常细胞(N)基因表达丰度值; T/N: 给药后肝癌细胞(T)基因表达丰度值/肝正常细胞(N)基因表达丰度值.

表2 FHD处理人肝癌细胞SMMC-7721后表达显著上调至正常的靶基因

Accession	Gene description	Ratio
		C/N	T/N
Hs.211601	Mitogen-activated protein kinase kinase kinase 12	0.45	1.0
Hs.99899	Tumor necrosis factor (ligand) superfamily, member 7	0.39	1.0
Hs.118825	Mitogen-activated protein kinase kinase 6	0.36	1.0
Hs.902	Neurofibromin-2 (bilateral acoustic neuroma)	0.24	1.0
Hs.1524	Tumor necrosis factor (ligand) superfamily, member 9	0.20	1.0

C/N: 肝癌细胞(C)基因表达丰度值/肝正常细胞(N)基因表达丰度值; T/N: 给药后肝癌细胞(T)基因表达丰度值/肝正常细胞(N)基因表达丰度值.