正常与硬化肝组织基因表达差异的初步分析

表1 肝硬化与正常肝组织基因表达差异情况

位置	比例	差值	基因	位置	比例	差值	基因
D7f		-46 583	placenta growth factor	D3a		-13 878	versican isoforms
F5l		-45 246	IL-inducible peptide	B1h		-13 644	BAK
F5e	0.170	-41 164	IL-13	A5b	0.204	-12 751	MEK1
C4b		-40 337	Wnt-5a	B3l	0.153	-12 644	DAP kinase 1
C7l		-39 092	RAR gamma	D7i	0.150	-12 490	GLG1
E2f	0.290	-36 259	emmprin	E6b	0.422	-12 411	catenin alpha-2
C3i	0.228	-35 930	Notch4	F6k		-12 372	TDGF1, 2, 3
A3i	0.080	-33 464	p19INK4d	D2c		-12 339	collagen type XI
C7m		-32 988	retinoid X receptor	A3j		-12 219	WEE1HU
D5f		-32 437	CD9	B1l		-11 664	FLAME-1
B2g	0.254	-32 317	TRIP	C2d		-11 434	ERCC5
C4k	0.146	-31 082	DVL	A7n		-11 310	desmin
B3j		-30 455	caspase-10	A5l		-11 230	TFDP2
C2j		-30 318	Rad	D2m		-11 077	tenascin-C
F2g	0.388	-30 177	endothelin ET2	F2f		-10 796	EGF-like growth factor
E4j	0.097	-30 058	CDC42	D4f		-10 779	GPIIIA; integrin beta3
D5k	0.085	-28114	ninjurin-1	A7g		-10 686	K4; CK4
B7j	0.250	-27 838	ABL2; ABLL	B2j		-10 436	C-IAP2; IAP1; MIHC
E7n		-27 258	HCK	A1c	0.203	-10 422	CDPK3
E2a		-26 725	MMP-19	A1e		-10 334	kinase PSSALRE
C6n		-26 592	sex gene	F3j	0.791	-10 331	EGR-1; KROX24; AT225
E2d	0.164	-26 409	TIMP-3;	B6d		-10 284	p55-c-fgr protein
E5m		-26 206	H-cadherin	C4n		-10 111	smoothened
D7g		-25 952	FLT3/FLK2	B7l	0.265	-9 485	STAT1
F5k		-25 326	IFN-gamma	B7k	0.444	-9 301	ZAP-70; ZAP70
D5g	0.170	-25 132	cytovillin 2	E4n	0.330	-8 337	P115
D6c	0.281	-23 356	semaphorin E	B4c	0.262	-8 173	WSL-LR; Apo-3
B3h	0.465	-23 309	FLICE; CAP4; CASP8; MCH5	D7n	0.353	-7 249	homeobox HOX 4A
C2n	0.087	-23 014	replication factor C	A3m	0.292	-7 008	NEDD5 protein homolog
D4b	0.136	-22 957	integrin alpha8	C3e	0.458	-6 939	RAD23
B2i	0.122	-21 022	CRAF1	A2e	0.351	-6 736	PCTAIRE-3
E4e		-20 262	P21-RAC2	A5a	0.367	-6 249	MAPKK 5;
B3i	0.536	-20 089	ICE-LAP6	E1k	0.449	-5 473	MMP-14 (MT1-MMP)
D5e	0.159	-19 823	cytohesin-1	A1i	0.455	-5 260	P23; P25; P35
F3k	0.137	-19 389	hepatocyte growth factor	C3b	0.352	-5 111	superoxide dismutase 1
E1m	0.095	-19 179	MMP-16 (MT3-MMP)	A4n	0.464	-4 929	JNK3; JNK3; P49
D6f	-18 894	semaphorin-1	A7a	0.352		-4 649	K16; CK 16;
E2b	0.636	-18 636	TIMP-1; EPA	C1m	0.380	-4 399	DNA TOPO I
C3j		-18 316	Jagged 1	B4d	0.473	-4 221	Akt1; c-Akt
C1a		-18 130	DNA-PK; XRCC7	A2f	0.449	-4 152	PITALRE
C6m		-17 970	CCK4; PTK7	D2e	2.162	10 343	collagen type XVIII
B2n	0.100	-17 919	TRAIL receptor	A5e		1 0747	PCNA; cyclin
D6h		-17 735	LAR	E1e	1.583	11 610	MMP-8; collagenase-2
A7d		-17 478	K1; CK 1	E3e	2.141	1 1693	NDK A; NM23-H1
C2c		-17 212	XRCC1	D3f		13 084	fibronectin
E1j		-17 010	MMP-13; collagenase-3	E6d		14 470	plakoglobin;
F6b		-16 980	NT-3	E3l		14 883	rhoB
B1k	0.644	-16 741	NIK	D4j	1.702	16 207	integrin beta7
B3f		-16 474	LICE2	A7m		16 433	vimentin
C5f		-15 882	eps15	D1b		16 589	byglycan
D6e		-15 220	semaphorin V	F4k		16 800	IL-5
B7g		-15 072	SKY	D1a	1.842	1 8757	CSPCP; aggrecan 1;
A6f		-14 898	b-raf	A6i		1 9497	c-myc binding protein
B5l	0.670	-14 354	rhoA	B5c		19 662	CD27BP (Siva)
E4i	0.181	-14 319	p160ROCK	A3e		28 403	mda-6; CAP20
F5d		-13 972	IL-12	F5n		32 402	MIF
C1i		-13 927	DNA polymerase	B5b		36 045	GST homolog
A4j	0.216	-13 888	ERK6; ERK5