基因表达谱芯片技术筛选NS5ATP11反式调节基因

表1 表达显著增加的基因

GenBank登陆号	编码蛋白	Cy5/Cy3
NM_014863	B cell RAG associated protein(GALNAC4S-6ST), mRNA B细胞重组激活蛋白结合蛋白	3.000
NM_003463	protein tyrosine phosphatase type IVA, member 1(PTP4A1), mRNA蛋白酪氨酸磷酸酶	3.042
NM_002736	protein kinase, cAMP-dependent, regulatory, type II, beta(PRKAR2B), mRNAcAMP依赖的蛋白激酶	3.175
NM_005627	serum/glucocorticoid regulated kinase(SGK), mRNA血清/糖皮质激素调节激酶	3.358
NM_004827	ATP-binding cassette, sub-family G(WHITE), member 2(ABCG2), mRNAATP结合盒亚家族G	3.453
NM_007268	Ig superfamily protein(Z39IG), mRNAIg超家族蛋白	3.564
D50683	mRNA for TGF-betaIIR alpha, complete cds转化生长因子b2Ra	3.939
NM_006096	N-myc downstream regulated gene 1(NDRG1), mRNA N-myc下游调节基因1	6.376

表2 表达显著下降的基因

GenBank登陆号	编码蛋白	Cy5/Cy3
NM_012248	selenophosphate synthetase 2 (SEPHS2)，mRNA磷酸硒合成酶2	0.161
NM_002388	minichromosome maintenance deficient 3 (S. cerevisiae) (MCM3)，mRNA小染色体维持缺陷3(酿酒酵母)	0.168
NM_002292	laminin，beta 2 (laminin S) (LAMB2)，mRNA层粘连蛋白B2	0.171
NM_001034	ribonucleotide reductase M2 polypeptide (RRM2)，mRNA核糖核苷酸还原酶M2多肽	0.174
NM_004184	tryptophanyl-tRNA synthetase (WARS)，mRNA色氨酸-tRNA合成酶	0.189
NM_001033	Homo sapiens tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity，collagenase inhibitor) (TIMP1)金属蛋白酶的组织抑制因子	0.223
NM_003254	TRAF and TNF receptor associated protein (TTRAP)，mRNATRAF、TNF受体结合蛋白	0.236
NM_016614	Homo sapiens mRNA for KIAA0968 protein，partial cds KIAA0968蛋白	0.245
AB023185	eukaryotic translation initiation factor 4A，isoform 1 (EIF4A1)，mRNA真核翻译起始因子4A	0.255
BC006997	Ras-GTPase-activating protein(GAP) SH3-domain-binding protein(G3BP)，mRNA Ras-GTP酶激活蛋白结合蛋白	0.256