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©The Author(s) 2003.
世界华人消化杂志. 2003-01-15; 11(1): 65-71
在线出版 2003-01-15. doi: 10.11569/wcjd.v11.i1.65
在线出版 2003-01-15. doi: 10.11569/wcjd.v11.i1.65
表1 Fundamental pathways altered by DNA methylation in cancer
| Pathway affected | Genes silenced by CpG island methylation |
| Cell cycle control | Rb, p16(INK4a), p15, p14(ARF), p73 |
| DNA damage repair | MLH1, O6MGMT, GSTp, BRCA1 |
| Inhibiting apoptosis | DAP-kinase, Caspase-8, TMS1 |
| Invasion tumor architecture | E-cadherin, VHL, APC, LKB1, TIMP3, Thrombospondin1 |
| Growth factor response | ER, RARb, Androgen Receptor, Endothelin B Receptor, RASSF1A |
引文著录: 周永宁, 徐采朴, 房殿春. CpG岛甲基化与胃肠道肿瘤. 世界华人消化杂志 2003; 11(1): 65-71