CircRASSF2靶向miR-218-5p调控胃癌细胞增殖、迁移和凋亡的研究

图1 circRASSF2和miR-218-5p负相关.

图2 circRASSF2和miR-218-5p结合位点. wt-circRASSF2: circRASSF2野生型载体; mut-circRASSF2: circRASSF2突变型载体.

图3 circRASSF2表达的检测. 与si-NC组相比, ^aP<0.05. si-NC: 小干扰RNA阴性对照; si-circRASSF2 a/b/c: circRASSF2的小干扰RNA a/b/c.

图4 miR-218-5p表达的检测. ^aP<0.05 vs si-NC组; ^bP<0.05 vs miR-NC组; ^cP<0.05 vs si-circRASSF2+anti-miR-NC组. si-NC: 小干扰RNA阴性对照; si-circRASSF2: circRASSF2的小干扰RNA; miR-NC: miRNA阴性对照; miR-218-5p mimic: miR-218-5p模拟物; anti-miR-NC: miRNA抑制剂阴性对照; miR-218-5p inhibitor: miR-218-5p抑制剂.

图5 增殖, 凋亡, 迁移的检测. si-NC: 小干扰RNA阴性对照; si-circRASSF2: circRASSF2的小干扰RNA; miR-NC: miRNA阴性对照; miR-218-5p mimic: miR-218-5p模拟物; anti-miR-NC: miRNA抑制剂阴性对照; miR-218-5p inhibitor: miR-218-5p抑制剂.