代谢相关脂肪性肝病是交感神经系统激活相关性疾病的研究进展

图1 交感神经激活对代谢途径和交感神经张力通过肾反射的维持的影响以及对心脏代谢调节的不利影响的概述. Citation: Carnagarin R, Tan K, Adams L, Matthews VB, Kiuchi MG, Marisol Lugo Gavidia L, Lambert GW, Lambert EA, Herat LY, Schlaich MP. Metabolic dysfunction-associated fatty liver disease (mafld)-a condition associated with heightened sympathetic activation. Int J Mol Sci 2021; 22: 4241.

图2 胃胀后, 经迷走神经传入迷走神经(绿线)到达NTS/AP的外周感觉信号. NTS向DMN投射. 该通路通过迷走神经(浅蓝线)调节葡萄糖产生、胃肠动力和激素释放(CCK; PYY; GLP-1)和胰腺分泌. VNS的作用部位由点紫线指示, 而减轻体重假想VBLOC的机制包括胃排空减少和胰腺外分泌抑制(虚红线). NTS: 孤束核; AP: 区前突复合体; DMN: 背侧运动核; CCK: 胆囊收缩素; PYY: 肽YY; GLP-1: 胰高血糖素样肽-1; VNS: 迷走神经刺激; VBLOC: 迷走神经阻滞. Citation: Guarino D, Nannipieri M, Iervasi G, Taddei S, Bruno RM. The role of the autonomic nervous system in the pathophysiology of obesity. Front Physiol 2017; 8: 665.