Efficacy of intra-tumor injection of Xiao-Zhi-Ling on transplanted hepatoma in rats

Table 1 Change of the parameters 3 days after injection ^-x±s

Indexes	Saline	XZL	Ethanol	F	P
Tumor volume (mm3)	48.02 ± 14.01	26.00 ± 5.41	20.30 ± 12.66	8.356	0.005
Tumor necrosis (mm3)	1.40 ± 0.55	3.20 ± 0.84	3.20 ± 0.10	7.364	0.008
Albumin (g/L)	34.02 ± 2.98	47.10 ± 18.31	32.88 ± 4.92	2.540	0.120
ALT (U/L)	96.80 ± 28.45	75.60 ± 17.87	150.60 ± 43.05	7.520	0.008
AST (U/L)	305.00 ± 117.72	209.00 ± 47.89	404.00 ± 45.50	7.778	0.007
ALP (U/L)	373.80 ± 78.02	184.40 ± 25.39	422.60 ± 52.18	25.119	0.000
Creatinine (μmol/L)	34.60 ± 1.95	38.60 ± 1.82	39.80 ± 4.38	4.228	0.041
PCNA	62.80 ± 12.62	40.60 ± 7.89	56.00 ± 12.06	5.288	0.023

Table 2 Change of the parameters 8 days after injection ^-x±s

Indexes	Saline	XZL	Ethanol	F	P
Tumor Volume (mm3)	464.62 ± 212.00	174.38 ± 109.46	147.58 ± 60.17	7.658	0.007
Tumor Necrosis(mm3)	1.60 ± 0.89	3.8 ± 0.45	3.6 ± 0.89	12.333	0.001
Albumin (g/L)	33.68 ± 5.66	36.88 ± 5.78	30.01 ± 2.67	2.447	0.128
ALT (U/L)	104.00 ± 43.39	68.80 ± 13.81	118.60 ± 42.72	2.522	0.122
AST (U/L)	341.00 ± 84.63	233.14 ± 52.28	328.20 ± 64.27	3.714	0.056
ALP (U/L)	237.40 ± 80.63	250.80 ± 75.24	474.0 ± 148.15	7.767	0.007
Creatinine (μmol/L)	38.40 ± 6.02	37.80 ± 6.38	36.60 ± 4.0	0.135	0.875
PCNA	56.20 ± 8.67	41.40 ± 10.00	58.80 ± 12.10	4.063	0.045

Table 3 MDDT of the tumor in groups S, X and E

Group	MD (3 days)	MD (8 days)	MDDT
Group S	4.56	9.62	4.51
Group X	4.6	6.74	10.75
Group E	3.54	6.5	5.9