Spontaneous viral clearance after 6-21 years of hepatitis B and C viruses coinfection in high HBV endemic area

Table 1 Clinical data for patients with HBV and/or HCV infection

	Group BC	Group B	Group C	Statistical value
Number of patients	40	16	31
Sex (male/female)	21/19	6/10	15/16	χ2 = 1.030, P > 0.05
Age (y)a	39 ± 5 (29-50)	40 ± 6 (31-53)	39 ± 3 (32-44)	F = 0.48, P > 0.05
Time of infection (y)a	16 ± 5 (14-21)	16 ± 5 (14-21)	17 ± 4 (14-21)	F = 2.27, P > 0.05
Serological markers (1994)
HBsAg +	34 (85.0%)	16 (100%)	0
HBeAg +	11 (27.5%)	7 (43.8%)	0
HBVDNA +	37 (92.5%)	14 (87.5%)	0
HCVRNA +	11 (27.5%)	0 (0%)	19 (61.3%)
Anti-HCV	39 (97.5%)	0 (0%)	31 (100.0%)

^aData were expressed as mean ± SD (range).

Table 2 Clearance of serum HBV markers in Group BC and Group B

	Group BC (n = 40, %)	Group B (n = 16, %)
HBsAg clearance
Until 1994	6 (15%)	0 (0%)
Until 2002	27 (67.5%)	8 (50%)
HBeAg clearance/seroconversion
HBeAg clearance
Until 1994	29 (72.5%)	10 (62.5%)
Until 2002	37 (92.5%)	14 (87.5%)
HBeAg seroconversion	22 (55.5%)	12 (75%)
HBV DNA clearance
Until 1994	3 (7.5%)	2 (12.5%)
Until 2002	35 (87.5%)	13 (81.2%)
HBV clearance	27 (67.5%)	7 (43.8%)
Male	18 (85.7%)a	4 (66.7%)
Female	9 (47.4%)b	3 (30%)
Low HBV DNA level group (< 105 copies/mL)	17 (70.8%)	4 (57.1%)
High HBV DNA level group (≥ 105 copies/mL)	10 (62.5%)	3 (33.3%)

Note.

^avs.

^bχ² = 6.686, P = 0.010.

Table 3 HCV RNA clearance rate in Group BC and Group C

	Group BC (n = 40, %)	Group C (n = 31, %)	Statistics value
HCV RNA clearance
Until 1994	29 (72.5%)a	12 (38.7%)b	χ2 = 8.173, (a vs. b) P < 0.05
Until 2002	35 (87.5%)c	10 (32.3%)d	χ2 = 22.963, (c vs. d) P < 0.001
Male	17 (80.9%)	3 (20%)
Female	18 (94.7%)	7 (43.8%)

Table 4 Relationship of serum HBV and HCV load in 1994

HCV RNA (copies/mL)	HBV DNA(copies/mL)			Total amount
	< 103	103-105	≥ 105
< 103	2	14	12	28
103-105	1	5	3	9
≥ 105	0	2	1	3
Total amount	3	21	16	40

P = 0.918.

Table 5 Type B ultrasonic presentations in patients with HBV and/or HCV infection

	Normal	Mild	Medium	Severe	Fatty liver	Not detected	Total
Group BC	4	0	2	1	3	30	10
Group B	8	0	2	0	3	3	13
Group C	0	13	14	1	2	1	31