Clinical and experimental study on therapeutic effect of umbilical cord blood transplantation on severe viral hepatitis

doi:10.3748/wjg.v9.i9.1999

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Sep 15, 2003 (publication date) through Jan 17, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Viral Hepatitis

World J Gastroenterol. Sep 15, 2003; 9(9): 1999-2003
Published online Sep 15, 2003. doi: 10.3748/wjg.v9.i9.1999

Table 1 Changes of biochemical parameters of patients before and after treatment (^-x±s)

Group	ALT (u·L^-1)		TBil (μmol·L^-1)		Alb (g·L^-1)		PTA (%)
Group	Before	After	Before	After	Before	After	Before	After
Control	112.4 ± 37.2	98.5 ± 23.6	315.1 ± 43.2	263.7 ± 105.2	31.3 ± 5.1	32.5 ± 2.6	33.5 ± 4.7	43.5 ± 6.7
UCBT	95.6 ± 31.9	84.3 ± 35.7	376.3 ± 55.1	203.1 ± 85.4^b^c	30.6 ± 4.2	35.6 ± 2.4^a	31.5 ± 3.6	45.8 ± 5.4^a
PE	116.3 ± 44.1	81.9 ± 42.5	356.6 ± 48.5	195.6 ± 103.7^b^c	28.5 ± 3.6	36.9 ± 5.1^b^c	28.8 ± 7.2	48.3 ± 7.5^b
UCBT+PE	104.5 ± 38.6	85.3 ± 36.2	405.7 ± 59.4	173.2 ± 125.6^b^c	30.7 ± 4.4	37.7 ± 3.5^b^c	29.7 ± 6.5	52.3 ± 10.2^b^c

^aP < 0.05 vs before treatment,

^bP < 0.01 vs before treatment,

^cP < 0.05 vs control group.

Table 2 Parameters of cellular and humoral immune of patients before and after treatment (^-x±s)

Group	Active T lymphocyte (%)		CD4⁺ lymphocyte (%)		CD8⁺ lymphocyte (%)		IL2 (u·mL^-1)
Group	Before	After	Before	After	Before	After	Before	After
Control	35.6 ± 7.5	44.1 ± 14.3	32.7 ± 5.3	35.6 ± 8.2	22.5 ± 3.6	23.7 ± 5.2	41.3 ± 10.5	48.6 ± 21.5
UCBT	33.2 ± 8.7	51.6 ± 12.5^a^b	30.5 ± 6.9	44.3 ± 11.6^a	23.2 ± 4.7	25.6 ± 9.5	44.5 ± 9.6	62.7 ± 28.6^a^b
PE	36.1 ± 6.3	42.7 ± 16.9	29.5 ± 8.2	34.7 ± 7.4	20.4 ± 6.9	26.7 ± 8.4	48.6 ± 11.3	51.3 ± 31.9
UCBT+ PE	31.9 ± 8.5	58.9 ± 25.4^a^b	27.1 ± 7.3	48.5 ± 21.3^a^b	18.3 ± 8.5	28.4 ± 11.2	36.2 ± 10.8	64.8 ± 27.5^a^b

^aP < 0.05 vs before treatment,

^bP < 0.05 vs control group.

Table 3 Biochemical parameters of rats after treatment (^-x±s)

Group	ALT(u·L^-1)	TBil (μmol·L^-1)	AFP(μg·L^-1)
Control group	1025.3 ± 36.9	78.6 ± 3.4	21.5 ± 13.8
Normal saline group	1016.8 ± 318.2	65.6 ± 18.3	23.7 ± 15.9
Adult plasma group	365.6 ± 118.4^a	36.2 ± 9.5^a	28.9 ± 18.7
Neonate cord blood group	186.7 ± 39.5^b^c	14.3 ± 6.0^b^c	686.4 ± 186.5^b^d

^aP < 0.05 vs control group and normal saline group,

^bP < 0.01 vs control group and normal saline group,

^cP < 0.05 vs adult plasma group,

^dP < 0.01 vs adult plasma group.

Table 4 Histological examinations of rats’ liver after treatment (^-x±s)

Groups	Ballooning degeneration	Fatty degeneration	Hepatocellular necrosis	Hepatocellular regeneration
Control group	+++	+++	+++	--
Normal saline group	+++	+++	+++	--
Adult plasma group	++	++	++	+
Neonate cord	+	+	+	+++
blood group

+++: Severe/extremely remarkable, ++: Medium, +: Mild, -: No/non-obvious.

Citation: Tang XP, Yang X, Tan H, Ding YL, Zhang M, Wang WL. Clinical and experimental study on therapeutic effect of umbilical cord blood transplantation on severe viral hepatitis. World J Gastroenterol 2003; 9(9): 1999-2003
URL: https://www.wjgnet.com/1007-9327/full/v9/i9/1999.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i9.1999