Mad2 and p53 expression profiles in colorectal cancer and its clinical significance

Table 1 Relationship between C/N ratio of Mad2 expression and histologic differentiation and lymph node metastasis

Groups	n	Mad2		Positive (%)	P
		C/N > 2	C/N < 2
Differentiation
WD	25	10	15	40%
MD	5	2	3	40%
PD	8	2	6	25%	aP = 0.737
Lymph node metastasis
Absent	32	9	23	28%
Present	6	5	1	83.3%	bP = 0.01

^a: Comparison among groups of colorectal cancer,

^b: Comparison between absent and present, WD: Well differentiated adenocarcinoma, MD: Moderately differentiated adenocarcinoma, PD: Poorly differentiated adenocarcinoma.

Table 2 Relationship between expression of Mad2 protein and histologic differentiation and lymph node metastasis

Groups	n	Mad2		Positive (%)	P
		+	-
Normal tissue	38	18	20	47.4%
Adenocarcinoma	38	33	5	86.8%	aP < 0.001
WD	25	23	2	92%
MD	5	5	0	100%
PD	8	5	3	62.5%	bP = 0.064
Lymph node metastasis
Absent	32	29	3	90.6%
Present	6	4	2	66.7%	cP = 0.169

^a: Comparison between normal tissue and adeocarcinama,

^b: Comparison among groups of colorectal cancer,

^c: Comparison between absence and presence.