Toxicities and therapeutic effect of 5-fluorouracil controlled release implant on tumor-bearing rats

Table 1 Changes of area of small intestinal mucosal cells (μm²)

Time (weeks)	Group A	Group B	Group C
2	38.98 ± 8.16	47.16 ± 3.29	31.32 ± 7.76b
4	35.07 ± 5.70	42.25 ± 4.42	28.81 ± 1.98b
6	38.11 ± 1.89	36.97 ± 3.44	30.17 ± 5.00
8	29.91 ± 1.34	-	29.72 ± 0.97
Mean	35.68 ± 5.78	42.13 ± 5.48a	30.00 ± 4.15ab

^aP < 0.05 vs group A;

^bP < 0.05 vs group B.

Table 2 Changes of IOD of inner mucosal surface of small intestine

Time (weeks)	Group A	Group B	Group C
2	0.406 ± 0.020	0.248 ± 0.069	0.453 ± 0.051
4	0.417 ± 0.110	0.290 ± 0.017	0.409 ± 0.024b
6	0.379 ± 0.042	0.335 ± 0.055	0.453 ± 0.081
8	0.508 ± 0.083	-	0.352 ± 0.041a
Mean	0.427 ± 0.080	0.295 ± 0.051a	0.417 ± 0.063b

^aP < 0.05 vs group A;

^bP < 0.05 vs group B.

Table 3 Changes of extraction of Evan’s blue from small intestine (μg·g^-1)

Time (weeks)	Group A	Group B	Group C
0	0.860 ± 0.051	0.840 ± 0.045	0.870 ± 0.035
1	0.903 ± 0.045	0.980 ± 0.145	0.847 ± 0.083
2	0.797 ± 0.086	1.123 ± 0.172	1.243 ± 0.169a
3	0.880 ± 0.240	1.273 ± 0.231	0.813 ± 0.081b
4	0.917 ± 0.349	1.275 ± 0.230	0.823 ± 0.067b
5	0.793 ± 0.100	1.320 ± 0.110a	0.863 ± 0.115b
6	0.993 ± 0.276	1.427 ± 0.227	0.813 ± 0.099b
7	0.890 ± 0.226	1.010 ± 0.014	0.923 ± 0.250
8	0.873 ± 0.116	-	0.853 ± 0.131
Mean	0.881 ± 0.183	1.253 ± 0.323a	0.898 ± 0.179b

^aP < 0.05 vs group A;

^bP < 0.05 vs group B.

Table 4 Contents of element F in group C in major organs (%)

Time(weeks)	Left lobeof liver	Right lobeof liver	Heart	Kidney
2	7.800 ± 0.804	0.782 ± 0.084a	0.143 ± 0.050ab	0.174 ± 0.144ab
4	6.560 ± 0.694	0.645 ± 0.233a	0.300 ± 0.131a	0.272 ± 0.136a
6	6.269 ± 1.383	0.784 ± 0.362a	0.288 ± 0.232a	0.141 ± 0.061ab
8	4.414 ± 0.482	0.334 ± 0.143a	0.162 ± 0.067a	0.184 ± 0.120a

^aP < 0.05 vs left lobe of the liver;

^bP < 0.05 vs right lobe of the liver.

Table 5 Changes of tumor volume and survival days in tumor-bearing rats

Group	Tumor volume (cm3)		Tumor inhibitionrates (%)	Survival days (d)
	6 days of transplantation	21 days of transplantation
Group D	0.021 ± 0.010	2.762 ± 1.384	-	28.0 ± 2.2
Group E	0.030 ± 0.014	1.844 ± 0.904	33.2	30.0 ± 3.2
Group F	0.027 ± 0.012	0.102 ± 0.117ab	96.3b	38.7 ± 6.7ab

^aP < 0.05 vs group D,

^bP < 0.05 vs group E.