Peroxisome proliferator-activated receptor gamma ligands inhibit cell growth and induce apoptosis in human liver cancer BEL-7402 cells

Table 1 Effect of 15d-PGJ2 and TGZ on cell cycle distribution and apoptosis in BEL-7402 cells

Treatment (µm)	%Cell cycle distribution			%apoptosis
	G0/G1	S	G2/M
Control	49.7 ± 1.5	34.8 ± 2.1	15.5 ± 1.1	2.1 ± 0.3
15d-PGJ2
10	50.5 ± 2.6	34.2 ± 1.7	15.3 ± 0.5	13.9 ± 1.1b
20	64.8 ± 2.9b	19.5 ± 1.5b	15.7 ± 0.2	33.5 ± 2.3b
30	71.6 ± 4.2b	14.1 ± 0.6b	14.4 ± 1.3	55.8 ± 4.7b
TGZ
10	54.2 ± 2.1	29.4 ± 1.3	16.6 ± 0.9	10.3 ± 1.1b
20	61.5 ± 3.1b	28.2 ± 1.7b	14.9 ± 1.7	25.5 ± 1.8b
30	68.9 ± 4.8b	14.2 ± 0.8b	16.9 ± 1.4	50.0 ± 4.1b

Cell cycle distribution was determined after 24 h of treatment in one group and apoptosis was determined after 48 h of treat-ment in the other group. The tabulated percentages were an average calculated on the results of three separate experiments. The value was represented as mean ± SEM (n = 3).

^bP < 0.01 versus corresponding control group.