Meta analysis of risk factors for colorectal cancer

doi:10.3748/wjg.v9.i7.1598

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Jul 15, 2003 (publication date) through Mar 2, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 15, 2003; 9(7): 1598-1600
Published online Jul 15, 2003. doi: 10.3748/wjg.v9.i7.1598

Table 1 Case-control studies on risk factors of colorectal cancer

No	Author	Area	Number of cases	Number of cases	Sources of references
1	JIAO Den-Ao	Jiashan	160	9	Zhonghua Liuxingbingxue Zazhi, 1988, 9(6):354-357
2	WU Den-Ren	Jiashan	114	5	Shiyong Zhongliu Zazhi, 1990, 5(2): 95-99
3	YANG Gong	Shanghai	850	2	Zhonghua Liuxingbingxue Zazhi, 1992, 13(1): 30-33
4	ZHANG Cao	Beijing	250	5	Zhonghua Liuxingbingxue Zazhi, 1992, 13(6):321-323
5	ZOU Run	Jiashan	41	10	Zhongguo Manxingbing Yufang Yu Kongzhi, 1993, 1(5): 213-215
6	MEN Fan-He	Guangdong	100	3	Diyi Junyi Daxue Xuebao, 1994, 14(4): 281-283
9	LIU Xi-Yong	Jiashan	286	6	Zhongguo Manxingbing Yufang Yu Kongzhi, 1994, 2(3): 122-124
7	YANG Gong	Shanghai	1328	4	Zhonghua Liuxingbingxue Zazhi, 1994, 15(5):299-303
8	YANG Gong			3	Zhongguo Zhongliu Linchuang, 1995, 22(6):403-408
10	LAI Kuang-De	Dalian	129	3	Zhongguo Manxingbing Yufang Yu Kongzhi, 1995, 3(3):106-109
11	HE Xi-Zhen	Shenyang	390	2	Shiyong Zhongliuxue Zazhi, 1996, 10(2): 64-65
12	YANG Gong	Shanghai	3166	3	Zhongliu, 1996, 16(2): 74-78
13	ZOU Run	Hangzhou	245	5	Zhejiang Yike Daxue Xuebao, 1996, 25(5): 204-206
4	LIU Ai-Zong	Hunan	153	7	Zhongguo Gonggong Weisheng, 1997, 13(4):206-207

Table 2 Results from meta-analysis of risk factors of colorectal cancer

Factors	Number of references	*Pooled OR and* 95%CI**	Factors	Number of references	*Pooled OR and* 95%CI**
(1) History of chronic diarrhea	7	4.80 (4.30-5.37)	(8) Pickled vegetables	3	1.86 (1.67-2.07)
(2) History of fecal mucohemorrhage	5	7.18 (5.06-10.21)	(9) High lipid food	3	3.16 (2.22-4.51)
(3) History of bowel polyps	5	12.69 (7.49-21.48)	(10) Proper physical activities	4	0.74 (0.72-0.77)
(4) History of constipation	4	2.23 (1.95-2.54)	(11) Alcohol drinking	5	1.06 (0.91-1.24)
(5) History of appendicitis	3	1.98 (1.71-2.28)	(12) Cigarette smoking	5	1.40 (1.10-1.77)
(6) Dietary fibers	5	0.79 (0.59-0.99)	(13) Emotional trauma	4	2.95 (2.81-3.09)
(7) Fish fry-cooked with soybean sauce	4	2.99 (2.69-3.35)	(14) Family history of cancers	7	2.27 (2.12-2.44)
(1) references: 1, 2, 5, 7, 9, 13, 14		(2) references: 1, 5, 7, 9, 13		(3) references: 1, 2, 5, 7, 12
(4) references: 1, 5, 7, 9		(5) references: 1, 2, 5		(6) references: 4, 6, 10, 11, 14
(7) references: 1, 5, 6, 7		(8) references: 2, 6, 14		(9) references: 4, 5, 14
(10) references: 4, 10, 13, 14		(11) references: 2, 5, 8, 13, 14		(12) references: 2, 5, 6, 8, 14
(13) references: 1, 4, 5, 7		(14) references: 1, 3, 4, 5, 6, 7, 14

Table 3 Results from stratified meta-analysis of risk factors of colorectal cancer

Factors	Strata	Pooled OR and 95% C.I.	Factors	Strata	Pooled OR and 95% C.I.
History of	CD^a	6.04 (5.45-6.70)	Pickled	CD	1.58 (1.20-2.07)
chronic	ND^a	3.99 (2.81-5.66)	vegetables	ND	2.30 (1.30-4.20)
diarrhea	Jca^b	7.01 (0.48-10.12)		Jc^a	1.70 (1.10-2.50)
	Zca^b	4.02 (1.13-14.21)		Zc^a	1.50 (1.01-2.30)
	HB	6.60 (2.46-11.21)		HB	2.30 (1.30-4.20)
	PB	4.50 (3.90-5.17)		PB	1.58 (1.20-2.07)
Fecal muco-	CD^b	9.81 (4.55-21.17)	Alcohol	CD^b	0.91 (0.71-1.17)
hemorrhage	ND^b	3.60 (2.80-4.80)	drinking	ND^b	1.65 (1.03-2.63)
	Jca^b	2.80 (0.75-10.46)		HB^b	1.65 (1.03-2.63)
	Zca^b	4.56 (2.12-9.81)		PB^b	0.91 (0.71-1.17)
History of	CD^a	7.40 (4.13-13.28)	Cigarette	CD^b	0.74 (0.43-1.27)
bowel polyps	ND^a	22.30 (12.40-40.01)	smoking	ND^b	1.92 (1.49-2.47)
	Jc^a	17.42 (14.54-20.85)		HB^b	1.92 (1.49-2.47)
	Zc^a	12.14 (3.07-28.00)		PB^b	0.74 (0.43-1.27)
History of	CD	2.53 (1.55-4.11)	Emotional	Jca^b	2.80 (1.51-3.28)
constipation	ND	1.90 (1.50-2.40)	trauma	Zca^b	1.63 (0.39-6.85)
	Jca^b	3.4 (1.02-11.39)		NOR	3.36 (2.21-5.12)
	Zca^b	0.89 (0.09-8.53)		SOU	2.53 (2.28-2.81)
Dietary fibers	CD^b	0.43 (0.18-0.97)	Proper	CD	0.79 (0.77-0.81)
	ND^b	1.02 (0.40-2.57)	physical	ND	0.57 (0.35-0.90)
	NOR^b	0.43 (0.18-0.97)	activities	NOR^a	0.69 (0.67-0.71)
	SOU^b	1.02 (0.40-2.57)		SOU^a	0.77 (0.70-0.85)
	HB^b	0.86 (0.58-0.96)		HB	0.57 (035-0.90)
	PB^b	0.37 (0.06-2.13)		PB	0.79 (0.77-0.81)
Fish fry-	CD	2.84 (2.31-3.48)	Family history	CD^a	1.76 (1.71-1.81)
cooked with	ND	3.20 (1.60-6.30)	of cancers	ND^a	3.73 (3.14-4.44)
soybean	Jca^b	7.01 (1.10-12.01)		Jca^a	2.84 (2.58-3.13)
	Zca^b	1.18 (0.30-8.01)		Zca^a	1.52 (1.34-1.72)
	HB	3.20 (1.60-6.30)		HB^a	3.73 (3.14-4.44)
	PB	2.84 (2.31-3.48)		PB^a	1.76 (1.71-1.81)

^a: No mutual involvement of OR by correspondent two ranges of 95%CI was found.

^b: At least one 95%CI of pooled OR was found including 1.00.

Citation: Chen K, Qiu JL, Zhang Y, Zhao YW. Meta analysis of risk factors for colorectal cancer. World J Gastroenterol 2003; 9(7): 1598-1600
URL: https://www.wjgnet.com/1007-9327/full/v9/i7/1598.htm
DOI: https://dx.doi.org/10.3748/wjg.v9.i7.1598