Expression of survivin in human gastric carcinoma and gastric carcinoma model of rats

Table 1 Correlation between expression of survivin and clinicopathological factors in human gastric carcinomas

Variables	Cases	Survivin expression n (%)	P
Chronic gastritis	20	1 (5%)	< 0.001
Gastric carcinoma	56	27 (48.2%)
Age
< 55	18	11 (61.1%)	0.184
> 55	38	16 (42.1%)
Invasion size
< 12.3 cm2	31	16 (51.6%)	0.571
> 12.3 cm2	25	11 (44.0%)
Invasion depth
Muscular layer unaffected	14	5 (35.7%)	0.280
Muscular layer affected	42	22 (52.4%)
Lymph node metastasis
Regional lymph	20	9 (45.0%)	0.720
Node unaffected
Regional lymph	36	18 (50%)
Node affected
Histological type	32	20 (62.5%)	0.013
(Lauren) intestinal
Diffuse	24	7 (29.2%)
Disease stage(TMN)
I	19	8 (42.1%)	0.873
II	8	4 (50.0%)
III	29	15 (51.7%)

Notes: The disease stage of each tumor was defined in accordance with the tumor-node-metastasis (TNM) classification, the histological type was classified according to Lauren, and other pathological variables were defined in accordance with the Gastric Carcinoma[14].

Table 2 Survivin expression in experimental gastric carcinoma

	Cases	Survivin expression	Positive rate (%)
Control (group B)	16	0	0
Group A
Antral mucosa of rats at week 20	10	4	40%a
Adenocarcinomas	23	18	78.3%b
Tissues adjacent to tumor	18	7	38.9%c

Ten rats of group A were killed at week 20, and the antral mucosa were examined. At week 35, all rats in both group A and B were killed and investigated. Tissues adjacent to tumor were defined as the tissues 5 mm away from the edge of tumor.

^aP < 0.05 vs control group,

^bP < 0.001 vs control group,

^cP < 0.01 vs control group.