Effect of arsenic trioxide on rat hepatocarcinoma and its renal cytotoxicity

Table 1 Relationship between tumor cells apoptotic rate in each group and treatment time (^-x±s)

Specimen	7 days	14 days	28 days
Group A	18.30 ± 3.43a	20.16 ± 5.31a	16.92 ± 4.03a
Group B	40.99 ± 5.89b	51.59 ± 7.67b	47.49 ± 3.23b
Group C	11.80 ± 7.02	12.24 ± 4.41a	10.77 ± 3.45a
Group D	22.41 ± 7.09a	17.31 ± 6.16a	13.88 ± 3.83a
Group E	7.66 ± 2.23	6.72 ± 2.31	6.30 ± 1.15

^aP < 0.05, vs group E;

^bP < 0.001, vs group E.

Table 2 Apoptosis distribution of tumor cells at G₀/G₁, G₂/M phase in each group (%)

Specimen	7 days		14 days		28 days
	G0/G1	G2/M	G0/G1	G2/M	G0/G1	G2/M
Group A	21.79a	10.67	24.93b	8.65	15.84	36.21a
Group B	23.43a	78.64b	42.53b	80.68b	27.90a	78.95b
Group C	5.97	25.50a	13.24	15.99	10.42	14.21
Group D	21.91a	40.33b	20.94a	25.71a	10.95	20.66
Group E	10.19	12.80	8.56	8.07	7.07	8.87

^aP < 0.05, vs group E;

^bP < 0.001, vs group E.

Table 3 Variety of tumor cells in each group (%)

Specimen	7 days			14 days			28 days
	G0/G1	S	G2/M	G0/G1	S	G2/M	G0/G1	S	G2/M
Group A	74.81a	5.65a	19.54a	80.17a	7.71a	12.12	85.16a	5.58a	9.25
Group B	54.04	12.63a	33.79a	69.50	8.50a	22.01a	67.83	11.14a	21.04a
Group C	60.34	6.45a	33.21a	66.92	11.18a	21.90a	62.63	12.21a	25.17a
Group D	44.71a	23.42a	31.94a	37.97a	30.64a	31.39a	32.84a	23.25	43.91a
Group E	58.89	29.93	11.18	63.47	26.21	10.33	66.54	22.07	11.4

^aP < 0.05, vs group E.