Protective effect of angelica sinensis polysaccharide on experimental immunological colon injury in rats

Table 1 Effect of ASP on CMDI, HS, OBT and MPO activity in colonic tissue of colitis rats (n = 8, ^-x±s)

Group	Dose (mg·kg-1)	CMDI	HS	OBT	MPO (U·g-1)
Control	-	0.0 ± 0.0	0.7 ± 1.1	0.0 ± 0.0	29 ± 18
Model	-	3.1 ± 1.1d	5.6 ± 0.8d	2.2 ± 0.8d	194 ± 32d
5-ASA	100	1.7 ± 0.6b	4.7 ± 0.7a	1.0 ± 0.9a	117 ± 15b
ASP	200	2.1 ± 0.5a	4.5 ± 1.3	1.4 ± 0.9	172 ± 16
ASP	400	1.8 ± 0.7a	4.3 ± 1.1a	1.1 ± 0.8a	158 ± 19a
ASP	800	1.5 ± 0.5b	4.1 ± 0.9b	0.8 ± 0.7b	133 ± 17b

^aP < 0.05,

^bP < 0.01, vs model group;

^dP < 0.01 vs normal group.

Table 2 Effect of ASP on activity of SOD and contents of MDA and NO in colonic tissue of colitis rats (n = 8, ^-x±s)

Group	Dose (mg·kg-1)	SOD (kU·g-1)	MDA (nmol·g-1)	NO (nmol·g-1)
Control	-	23.16 ± 5.13	27.41 ± 9.66	294 ± 73
Model	-	8.41 ± 3.17d	83.47 ± 22.53d	568 ± 65d
5-ASA	100	15.26 ± 2.14b	55.32 ± 8.61b	367 ± 26b
ASP	200	11.95 ± 3.22a	67.31 ± 13.84	496 ± 52a
ASP	400	14.84 ± 2.45b	58.52 ± 14.36a	445 ± 47b
ASP	800	16.27 ± 1.96b	49.14 ± 10.73b	381 ± 34b

^aP < 0.05,

^bP < 0.01, vs model group;

^dP < 0.01 vs normal group.

Table 3 Effect of ASP on levels of TNF-α, IL-2, IL-10 in colonic tissue of colitis rats (n = 8, ^-x±s)

Group	Dose (mg·kg-1)	TNF-α (kU·g-1)	IL-2 (A)	IL-10 (ng·g-1)
Control	-	30.6 ± 12.6	0.176 ± 0.028	43 ± 8
Model	-	82.8 ± 18.6d	0.381 ± 0.069d	15 ± 5d
5-ASA	100	45.3 ± 21.9b	0.264 ± 0.042b	22 ± 10
ASP	200	61.9 ± 25.6	0.318 ± 0.032a	23 ± 11
ASP	400	57.4 ± 20.8a	0.303 ± 0.036a	23 ± 8a
ASP	800	51.7 ± 21.5b	0.285 ± 0.031b	26 ± 10a

^aP < 0.05,

^bP < 0.01, vs model group;

^dP < 0.01 vs normal group.