Effect of complex amino acid imbalance on growth of tumor in tumor-bearing rats

Table 1 Compositions of amino acid solution (g·L^-1)

Amino acids	Group A	Group B	Group C	Group D
Isoleucine	5.5	5.5	5.5	5.5
Leucine	7.5	7.5	7.5	7.5
Lysine	7.0	7.0	7.0	7.0
Methionine	6.0	—	6.0	—
Phenylalanine	4.0	4.0	4.0	4.0
Threonine	5.0	5.0	5.0	5.0
Tryptophan	1.5	1.5	1.5	1.5
Valine	6.0	6.0	—	—
Arginine	6.0	6.0	6.0	6.0
Histidine	3.0	3.0	3.0	3.0
Proline	4.0	4.0	4.0	4.0
Tyrosine	1.0	1.0	1.0	1.0
Alanine	20.0	20.0	20.0	20.0
Glycine	7.5	7.5	7.5	7.5
Aspartic acid	4.0	4.0	4.0	4.0
Total amino acid	88.0	82.0	82.0	76.0
Total nitrogen	14.1	13.1	13.1	12.2

Table 2 Distribution of cancer cell cycle after EN treatment (%)

Phase	Group A	Group B	Group C	Group D
G0G1	67.0 ± 5.1	78.9 ± 8.5ac	69.2 ± 6.2b	80.5 ± 9.0ac
S	20.1 ± 1.8	11.8 ± 2.9ac	19.9 ± 3.0b	10.2 ± 2.1ac
G2+M	12.9 ± 3.2	9.2 ± 3.1	10.9 ± 2.5	9.4 ± 3.8
PI(S+G2+M)	33.0 ± 4.3	21.0 ± 5.0ac	30.8 ± 5.6b	20. 5 ± 2.8ac

^aP < 0.05, vs group A,

^bP < 0.05, vs group B,

^cP < 0.05, vs group C

Table 3 Changes in tumor volumes, IRT and MST before and after treatment

Group	Tumor volumes		IRT(%)	MST(d)
	Before	After
Group A	0.028 ± 0.015	2.85 ± 0.43	...	26.8 ± 1.5
Group B	0.039 ± 0.010	1.79 ± 0.56a	37.2	32.0 ± 2.6a
Group C	0.033 ± 0.020	1.90 ± 0.30ab	33.3	35.6 ± 3.2a
Group D	0.031 ± 0.011	1.60 ± 0.40abc	43.9	39.4 ± 3.0abc

^aP < 0.05, vs group A,

^bP < 0.05, vs group B,

^cP < 0.05, vs group C.