Effects of long-term tea polyphenols consumption on hepatic microsomal drug-metabolizing enzymes and liver function in Wistar rats

Table 1 Effects of long-term TPs consumption on microsomal enzymes

	Group		P450 nmol/mg MS pro	b5 nmol/mg MS pro	ADM mmol/mg MS pro/min	GST U/mgpro
♂	High dose (n = 10)		2.66 ± 0.55a	10.43 ± 2.78a	0.90 ± 0.12	24.66 ± 4.06
	Low dose (n = 10)		1.94 ± 0.90	7.82 ± 1.66	0.94 ± 0.11	27.05 ± 4.59
	Control (n = 10)		1.08 ± 1.04	5.51 ± 2.98c	0.92 ± 0.11c	25.88 ± 4.02
♀	High dose (n = 10)		0.66 ± 0.42	11.74 ± 2.31	0.91 ± 0.08b	29.48 ± 4.16
	Low dose (n = 10)		0.66 ± 0.38	11.34 ± 3.17	0.73 ± 0.09	26.44 ± 4.54
	Control (n = 10)		0.36 ± 0.18	13.42 ± 1.85	0.82 ± 0.08	29.40 ± 4.19

^aP < 0.01 vs ♂ control,

^bP < 0.05 vs ♀ control,

^cP < 0.05 vs ♀ control.

Table 2 Effects of long-term TPs consumption on major biochemical parameters of rat liver

	Group	ALT U/L	AST U/L	TP g/L	ALB g/L
♂	High dose (n = 10)	76.31 ± 32.0	294.69 ± 68.8	75.26 ± 3.44	32.96 ± 1.39
	Low dose (n = 10)	74.75 ± 11.62	285.4 ± 54.95	78.75 ± 1.83	32.71 ± 1.34
	Control (n = 10)	65.5 ± 9.89	271.5 ± 37.32	80.97 ± 3.43	32.42 ± 1.90
♀	High dose (n = 10)	59.15 ± 9.14	247.3 ± 61.03	81.43 ± 3.87	34.64 ± 1.11
	Low dose (n = 10)	50.31 ± 22.32	213.15 ± 75.92	78.76 ± 5.31	34.86 ± 2.30
	Control (n = 10)	56.92 ± 7.62	236.08 ± 51.94	79.56 ± 2.35	35.63 ± 1.06

ALT: serum alanine transaminase, AST: serum asparate transaminase, TP: total protein, ALB: albumin.