Effect of body mass index on adenocarcinoma of gastric cardia

Table 1 Mean levels of BMI in each age group of patients and healthy control subjects

Age	Patient group		Control group
	Number of cases	Median level of BMI	Number of cases	Median level of BMI
30-39	8	21.94	50	24.26
40-49	27	22.37	69	25.54
50-59	84	22.64	55	24.71
60-69	134	23.46	54	24.93
70-79	47	22.25	30	24.38
Total	300	22.90	258	24.85

Table 2 Mean levels of BMI in each sex group of patients and healthy control subjects

Gender	Patient group		Control group
	Number of cases	Median level of BMI	Number of cases	Median level of BMI
Male	249	22.88	115	24.75
Female	51	23.02	143	24.94
Total	300	22.90	258	24.85

Table 3 Odds ratios (ORs) and 95% confidence intervals (CIs) with body mass index (BMI) by age and sex

Age	Sex	BMI group	Studied group		Total	ORs	95%	CIs
			Control	Patient
1a	Male	UWc	2	16	18	2.42	0.56	10.53
		NMd	19	84	103	1.55	0.80	3.03
		OWe	20	42	62	0.45	0.23	0.89
		OBf	4	16	20	1.15	0.37	3.65
		TOTAL	45	158	203
	Female	UW	0	5	5	-	-	-
		NM	18	12	30	1.01	0.40	2.55
		OW	18	8	26	0.56	0.21	1.49
		OB	11	6	17	0.78	0.26	2.36
		TOTAL	47	31	78
2b	Male	UW	2	11	13	4.68	1.13	19.40
		NM	26	45	71	1.66	0.88	3.13
		OW	26	31	57	0.87	0.46	1.68
		OB	16	4	20	0.16	0.05	0.44
		TOTAL	70	91	161
	Female	UW	1	6	7	40.7	9.32	177.92
		NM	45	7	52	0.61	0.22	1.66
		OW	35	6	41	0.75	0.26	2.12
		OB	15	1	16	0.28	0.04	2.05
		TOTAL	96	20	116

a. Age group 1: ≤ 60 yrs, b. Age group 2: > 60 yrs, c. UW = underweight (BMI < 18.5 kg/m²), d. NM = Normal (18.5 ≤ BMI<24 kg/m²), e. OW = Overweight (24 ≤ BMI < 28 kg/m²), f. OB = Obesity (BMI ≥ 28 kg/m²).

Table 4 Fisher's exact test for evaluation of significance of association between underweight and high relative risk for GCA

Age	Sex	χ2 value	P	Monte carlo sig. (2-sided)
				99% confidence interval
				Lower bound	Upper bound
1a	Male	5.357	0.136	0.127	0.144
	Female	8.161	0.036	0.031	0.041
2b	Male	16.438	0.001	0.000	0.002
	Female	17.196	0.001	0.000	0.001

a. Age Group 1: ≤ 60 yrs, b. Age Group 2: > 60 yrs.

Table 5 Logistic regression analysis of sex, BMI and age group 1

	B	SEa	P	OR	95%	CIs
Sex	-1.714	0.210	< 0.01	0.180	0.119	0.272
BMI	-0.152	0.028	< 0.01	0.859	0.813	0.907
Age group1b	1.082	0.198	< 0.01	2.952	2.002	4.351
Constant	4.473	0.777	< 0.01	87.589

a. SE = standard error, b. Age group1: The subjects were divided into two age subgroup: age ≤ 60 yrs and age > 60 yrs.

Table 6 Logistic regression analysis of sex, BMI and age group 2

	B	SEa	P	OR	95%	CIs
Sex	-1.668	0.214	< 0.01	0.189	0.124	0.287
BMI	-0.156	0.029	< 0.01	0.856	0.809	0.905
Age group2b	0.609	0.090	< 0.01	1.838	1.541	2.193
Constant	4.105	0.790	< 0.01	60.662

a. SE = standard error, b. Age group 2: The subjects were divided into 5 10-year age subgroups (30-39 yrs, 40-49 yrs, 50-59 yrs, 60-69 yrs, 70-79 yrs, etc.).