Effect of NF-κB and p38 MAPK in activated monocytes/macrophages on pro-inflammatory cytokines of rats with acute pancreatitis

Table 1 Levels of AMS and ascites of AEP and ANP (¯x±s)

Group	AMS (IU/L)		Ascites (g)
	3 h	6 h	3 h	6 h
Sham	792.80 ± 265.08	793.8 0 ± 265.08	0	0
AEP	3056.00 ± 1232.35b	3187.17 ± 821.16b	1.43 ± 1.02b	2.56 ± 1.21b
ANP	4345.30 ± 1005.77ab	4865.12 ± 890.34ab	3.32 ± 1.01ab	3.76 ± 1.12ab

^bP < 0.01 vs sham,

^aP < 0.05 vs AEP.

Table 2 Macrocopic appearance and edema of pancreas in AEP and ANP (at 6 h after of model)

	n	Sham	AEP	ANP
Score	0.2	1.1	6.9a	6.3ac
ww/dw	4.3	5.3	7.1a	8.2ac

The macroscopic appearance of the pancreas was scored. For an individual rat the highest possible score was 9. Pancreatic water content was estimated as the wet weight/dry weight ratio (ww/dw) of the tissue. N: untreated animals, anesthesia omitted; S: sham operations.

^aP < 0.05 compared to the untreated group;

^cP < 0.05 compared to the control group at 6 h after induction of model.

Table 3 Serum levels of TNF-α and IL-6 in AEP and ANP (¯x±s)

Group	TNF-α (pg/mL)		IL-6 (pg/mL)
	3 h	6 h	3 h	6 h
Sham	4.13 ± 2.5	55.87 ± 3.79	100.79 ± 53.89	151.04 ± 91.79
AEP	54.27 ± 23.48b	67.83 ± 22.02b	428.12 ± 140.30b	420.13 ± 139.40b
ANP	64.28 ± 20.79b	106.59 ± 43.71abc	1600.32 ± 309.78ab	2203.76 ± 640.85abc

^bP < 0.001 vs sham group;

^aP < 0.05 or 0.001 vs AEP group;

^cP < 0.05 vs 3 h group.