Li C, Wu MY, Liang YR, Wu XY. Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma. World J Gastroenterol 2003; 9(11): 2395-2399 [PMID: 14606063 DOI: 10.3748/wjg.v9.i11.2395]
Corresponding Author of This Article
Dr. Chun Li, Department of Pathology, Medical College, Shantou University, Shantou, 515031 Guangdong Province, China. chli@stu.edu.cn
Article-Type of This Article
Esophageal Cancer
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Gastroenterol. Nov 15, 2003; 9(11): 2395-2399 Published online Nov 15, 2003. doi: 10.3748/wjg.v9.i11.2395
Table 1 Relationship between differentiation degree and telomerase activity in 60 cases of ESCC
Tumor stage
Sample (n)
Positive (n)
Positive rate (%)
P value
I
15
9
60
II
33
30
90.9
P < 0.05
III
12
11
91.6
Table 2 Relationship between telomerase activity and lymphatic metastasis
Sample (n)
Lymphatic metastasis
Telomerase activity
P value
+
-
41
+
37
4
P < 0.05
19
-
12
7
Table 3 Intensity of hTERT and hTP-1 mRNA expression in esophageal carcinoma tissues
Tumor stage
hTERT
P value
hTP-1
P value
n
-
+
++
+++
Positive rate (%)
-
+
++
+++
Positive rate (%)
I
15
7
4
3
1
53.3
7
5
3
0
53.3
II
33
6
7
11
9
81.8
P > 0.05
8
6
12
7
75.8
P > 0.05
III
12
2
2
4
4
83.3
2
2
5
3
83.3
Table 4 Relationship between hTERT, hTP-1 expression and telomerase activity
Telomerase activity
hTERT
P value
TP-1
P value
+
-
+
-
+
41
9
P < 0.05
38
12
P > 0.05
-
4
6
5
5
Citation: Li C, Wu MY, Liang YR, Wu XY. Correlation between expression of human telomerase subunits and telomerase activity in esophageal squamous cell carcinoma. World J Gastroenterol 2003; 9(11): 2395-2399