Copyright
©The Author(s) 2003.
World J Gastroenterol. Jan 15, 2003; 9(1): 9-15
Published online Jan 15, 2003. doi: 10.3748/wjg.v9.i1.9
Published online Jan 15, 2003. doi: 10.3748/wjg.v9.i1.9
Table 1 Ratio of expression level for a set of genes with the largest loading scores in the first two principal components
Component 1 | Component 2 | ||||
Gene | Ratio ELCA/LaCa | Ratio BCH/N | Gene | Ratio BCH/N | Ratio DYS/CAIN |
GAF | 131 | 16 | PCTK1 | 122 | 8 |
CAPR | 582 | 25 | DAXX | 5 | 95 |
CASP8 | 743 | 37 | P70 | 7 | 62 |
MMP16 | 143 | 17 | CCNH | 174 | 87 |
DCC Precursor | 316 | 12 | CD153 antigen | 70 | 31 |
Tenascin-R | 742 | 21 | TLAA | 9 | 39 |
ZAP70 | 157 | 83 | XPG | 90 | 26 |
IL-13 | 110 | 22 | Apoptosis Inhibitor Survivin | 3 | 107 |
TRAIL receptor | 66 | 82 | Bcl-1 oncogene | 122 | 19 |
LaCa/ELCA | N/BCH | N/BCH | CAIN/DYS | ||
BMP5 | 284 | 170 | MERLIN | 3 | 411 |
MIF | 79 | 72 | LERK-8 | 31 | 334 |
N-myc | 14 | 110 | DSG2; HDGC | 355 | 395 |
RPSA | 19 | 68 | MMP11 | 2 | 271 |
RBL2 | 33 | 18 | CDK2 | 13 | 51 |
RAD52 | 27 | 9 | CLK1 | 60 | 798 |
RBQ1 | 15 | 55 | MDMX | 3 | 225 |
Table 2 Ratio of expression level for a set of genes with the largest loading scores in the third principal components
Gene | Ratio N/BCH | Ratio DYS/BCH |
Bcl-2L8 | 803 | 227 |
SRC1 | 333 | 141 |
Muscle cadherin precursor | 299 | 111 |
Neurogenic locus notch protein | 488 | 104 |
CASP3 | 232 | 92 |
BCL2A1; GRS protein | 133 | 665 |
Type 1 cytoskeletal 10 protein | 302 | 370 |
TRAF5 | 83 | 650 |
Transcription factor E2F5 | 615 | 30 |
MAP kinase p38 | 147 | 86 |
BCH/N | BCH/DYS | |
KRT7 | 2 | 105 |
GRB-IR | 5 | 96 |
GAS1 | 4 | 210 |
BMP8 | 21 | 21 |
DVL | 12 | 187 |
CAM-PDE1B | 18 | 18 |
Apotosis regulator bcl-2 | 60 | 59 |
Table 3 Genes up or down regulated in all five stages of grade II basal cell hyperplasia, high-grade dysplasia, carcinoma in situ, early and advanced squamous cell carcinoma. Position indicates the gene position on the microarray membrane
Position | Gene Name |
Up Regulated Genes | |
A2k | G1/S-specific cyclin C |
A4i | ERK5 |
A4j | ERK6 |
A5b | ERK activator kinase 1 |
A5l | transcription factor DP2 |
B3g | caspase-8 precursor |
B3i | caspase-9 precursor |
B3j | caspase-10 precursor (CASP10) |
C1a | DNA-dependent protein kinase |
C2c | DNA-repair protein XRCC1 |
C2j | RAD1 |
C4b | Wnt-5A |
C4k | DVL1 |
C6m | CCK4 |
C7k | retinoic acid receptor epsilon |
C7l | retinoic acid receptor gamma 1 |
C7m | retinoic acid receptor beta |
D4b | integrin alpha 8 |
D4j | integrin beta 7 precursor |
D4k | integrin beta 8 precursor |
D5g | ezrin; cytovillin 2; villin 2 |
D5j | CD56 antigen |
D7f | placenta growth factor 1 |
E1f | MMP9 |
E2a | MMP18 |
F3j | early growth response protein 1 |
F4l | IL-6 |
F5e | IL-13 |
F5k | interferon gamma precursor |
F5l | leukocyte interferon-inducible peptide |
Down regulated Genes | |
C6c | insulin-like growth factor binding protein 2 (IGFBP2P2) |
F4d | interleukin-1 receptor antagonist protein precursor (IL-1RA; IRAP) |
- Citation: Zhou J, Zhao LQ, Xiong MM, Wang XQ, Yang GR, Qiu ZL, Wu M, Liu ZH. Gene expression profiles at different stages of human esophageal squamous cell carcinoma. World J Gastroenterol 2003; 9(1): 9-15
- URL: https://www.wjgnet.com/1007-9327/full/v9/i1/9.htm
- DOI: https://dx.doi.org/10.3748/wjg.v9.i1.9