Zhou J, Zhao LQ, Xiong MM, Wang XQ, Yang GR, Qiu ZL, Wu M, Liu ZH. Gene expression profiles at different stages of human esophageal squamous cell carcinoma. World J Gastroenterol 2003; 9(1): 9-15 [PMID: 12508342 DOI: 10.3748/wjg.v9.i1.9]
Corresponding Author of This Article
Zhi-Hua Liu, Ph.D. Professor, National Laboratory of Molecular Oncology, Cancer Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China. liuzh@pubem.cicams.ac.cn
Article-Type of This Article
Esophageal Cancer
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World J Gastroenterol. Jan 15, 2003; 9(1): 9-15 Published online Jan 15, 2003. doi: 10.3748/wjg.v9.i1.9
Gene expression profiles at different stages of human esophageal squamous cell carcinoma
Jin Zhou, Li-Qun Zhao, Mo-Miao Xiong, Xiu-Qin Wang, Guan-Rui Yang, Zong-Liang Qiu, Min Wu, Zhi-Hua Liu
Jin Zhou, Xiu-Qin Wang, Min Wu, Zhi-Hua Liu, National Laboratory of Molecular Oncology, Cancer Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China
Li-Qun Zhao, Guan-Rui Yang, Zong-Liang Qiu, Medical Science Institute of Henan Province, Zhengzhou 450052, China
Mo-Miao Xiong, Health Genetics Center, School of Public Health, The University of Texas Houston, Houston, TX 77225, United Statesute
Author contributions: All authors contributed equally to the work.
Supported by China Key Program on Basic Research, No. G1998051021; the Chinese Hi-tech R&D program, No. 2001AA231310 and National Natural Science Foundation of China, No. 30170519
Correspondence to: Zhi-Hua Liu, Ph.D. Professor, National Laboratory of Molecular Oncology, Cancer Institute, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China. liuzh@pubem.cicams.ac.cn
Telephone: +86-10-67723789 Fax: +86-10-67715058
Received: May 6, 2002 Revised: May 23, 2002 Accepted: July 26, 2002 Published online: January 15, 2003
Abstract
AIM: To characterize the gene expression profiles in different stages of carcinogenesis of esophageal epithelium.
METHODS: A microarray containing 588 cancer related genes was employed to study the gene expression profile at different stages of esophageal squamous cell carcinoma including basal cell hyperplasia, high-grade dysplasia, carcinoma in situ, early and late cancer. Principle component analysis was performed to search the genes which were important in carcinogenesis.
RESULTS: More than 100 genes were up or down regulated in esophageal epithelial cells during the stages of basal cell hyperplasia, high-grade dysplasia, carcinoma in situ, early and late cancer. Principle component analysis identified a set of genes which may play important roles in the tumor development. Comparison of expression profiles between these stages showed that some genes, such as P160ROCK, JNK2, were activated and may play an important role in early stages of carcinogenesis.
CONCLUSION: These findings provided an esophageal cancer-specific and stage-specific expression profiles, showing that complex alterations of gene expression underlie the development of malignant phenotype of esophageal cancer cells.
