Effects of recombinant human growth hormone on rat septic shock with intraabdominal infection by E. coli

Table 1 Effects of rhGH on mean arterial pressure (MAP) (^-x±s) and survival rate within 1 week in rat septic shock

Group	MAP (mmHg)		Survival rate within 1 week (%)
	1 d	3 d
C	124.6 ± 13.9		100.0
S	67.4 ± 22.6b	98.9 ± 23.2ad	46.2
T	114.4 ± 15.9ad	109.9 ± 10.2a	84.6f

^aP < 0.05,

^bP < 0.01, vs group C,

^dP < 0.01, vs group S in 1 d;

^fP < 0.01, vs group S.

Table 2 Effect of rhGH on leukocyte count in rat septic shock (^-x±s)

Time	Leukocyte ( × 109/L)			Neutrophil (%)
	Group C	Group S	Group T	Group C	Group S	Group T
1 d		8.42 ± 2.44	9.61 ± 3.58		28.75 ± 8.83a	36.77 ± 11.84bc
	7.73 ± 4.57			16.14 ± 6.0
3 d		6.75 ± 2.18	6.07 ± 2.45		13.74 ± 7.06	14.96 ± 5.35

^aP < 0.05,

^bP < 0.01, vs group C;

^cP < 0.05, vs 1 d in group S.

Table 3 Effects of rhGH on the concentrations of plasma en-dotoxin and TNFα in rat septic shock

Time	Endotoxin (U·L-1)			TNFα (μg·L-1)
	Group C	Group S	Group T	Group C	Group S	Group T
1 d		256 ± 52a	150 ± 39bc		3.59 ± 0.69b	3.66 ± 1.33b
	111 ± 53			2.88 ± 0.74
3 d		189 ± 52a	108 ± 42d		2.23 ± 1.09	1.54 ± 0.36ad

^aP < 0.01,

^bP < 0.05, vs group C;

^cP < 0.01,vs group S in 1 d;

^dP < 0.01, vs group S in 3 d.