Pathological characteristics, PCNA labeling index and DNA index in prognostic evaluation of patients with moderately differentiated hepatocellular carcinoma

Table 1 The relationship between pathological characteristics and TFS

Variables	n	The probability of TFS (%)
		1-year	3-year	5-year
Tumor nodule
Single	36	72.2	44.4	33.3
Multiple	15	40.0a	13.3a	6.7
Tumor diameter
≤ 5 cm	30	86.7	53.3	43.3
> 5 cm	21	33.3b	9.5b	4.8b
Tumor necrosis
No	35	77.1	42.9	34.3
Yes	16	31.3b	18.8	12.5
Tumor emboli
No	26	76.9	50.0	42.3
Yes	19	36.8b	10.5b	0b
Daughter nodules
No	30	80.0	40.0	30.0
Yes	15	20.0b	20.0	13.3
Infiltrated lymphocytes
Many	9	88.9	66.7	44.4
A few or none	42	59.5	31.0	23.8
Capsule
Thick	13	69.2	46.2	30.8
None or thin	32	56.3	28.1	21.9

^aP < 0.05 vs the above group,

^bP < 0.01 vs the above group.

Table 2 The relationship of pathological characteristics to DI and PCNA-LI

Variables	n	Diameter (cm)	Multiple nodules	Tumor necrosis	Tumor embolia	Daughter nodulesa
DI
Euploid	8	4.30 ± 1.97	2	1	0/6	0/6
Aneuploid	22	3.64 ± 1.29	5	4	8/19	4/19
DI < 1.5
Aneuploid	21	6.34 ± 2.65be	8	11	11/20	11/20d
DI > 1.5
PCNA-LI
< 5%	13	4.09 ± 1.44	0	1	0/10	2/10
5%-15%	20	4.53 ± 2.50	10c	4	8/18	3/18
> 15%	18	5.78 ± 2.60b	5	11ce	11/17c	10/17e

^aThe denominator was the number of observed cases, the nu-merator was the number of those presenting tumor emboli or satellite nodules.

^bP < 0.05,

^cP < 0.01 compared with the first group;

^dP < 0.05,

^eP < 0.01 compared with the second group.

Table 3 PCNA-LI in different DI groups

DI	n	PCNA-LI (%)
Euploid	8	5.076 ± 3.904
Aneuploid DI < 1.5	22	9.300 ± 6.896a
Aneuploid DI > 1.5	21	15.113 ± 9.527bc

^aP < 0.05,

^bP < 0.01 compared with the first group, respectively;

^cP < 0.05 compared with the second group.

Table 4 The DNA-index distribution in different PCNA groups

PCNA-LI	n	Euploidy	Aneuploidy DI < 1.5	Aneuploidy DI > 1.5
< 5%	13	5	6	2
5%-15%	20	3	11	6
> 15%	18	0	5	13

χ² test P < 0.01, compared aneuploidy DI > 1.5 and the others among the groups.