Liver Cancer
Copyright ©The Author(s) 2002. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastroenterol. Dec 15, 2002; 8(6): 1040-1044
Published online Dec 15, 2002. doi: 10.3748/wjg.v8.i6.1040
Pathological characteristics, PCNA labeling index and DNA index in prognostic evaluation of patients with moderately differentiated hepatocellular carcinoma
Wen-Jiao Zeng, Guo-Yuan Liu, Jie Xu, Xin-Da Zhou, Yue-E Zhang, Nong Zhang
Wen-Jiao Zeng, Guo-Yuan Liu, Jie Xu, Yue-E Zhang, Nong Zhang, Department of Pathology, Medical School of Fudan University, Shanghai 200000, China
Xin-Da Zhou, Liver Cancer Research Institute of Fudan University, Shanghai 200000, China
Author contributions: All authors contributed equally to the work.
Supported by the Foundation of the Minister of Science and Technology, No 96-906-01-15
Correspondence to: Dr. Nong Zhang, Department of Pathology, Medical School of Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China. zhangnong@shmu.edu.cn
Telephone: +86-21-54237537 Fax: +86-21-65649416
Received: May 11, 2002
Revised: April 22, 2002
Accepted: June 9, 2002
Published online: December 15, 2002
Abstract

AIM: To study the relationship between prognosis and pathological characteristics, proliferating cell nuclear antigen labeling index (PCNA-LI) and DNA index (DI) in patients with moderately differentiated hepatocellular carcinoma(HCC).

METHODS: 51 cases of moderately differentiated HCC were analyzed with respect to the relation between their clinical follow-up data and pathological characteristics. Meanwhile, PCNA-LI of HCC cells was detected by immunohistochemistry assay and DI was measured by Feulgen staining and automatic image analysis technique.

RESULTS: Patients with a single tumor nodule, less than 5 cm in diameter, no tumor emboli, no daughter nodules and necrosis had relatively better prognosis; patients with euploidy HCC had better prognosis than those with aneuploidy; among the aneuploidy patients those with DI < 1.5 had better prognosis than the cases with DI > 1.5; The higher the PCNA-LI, the worse would be the prognosis. The increase in DI was correlated with the increase in PCNA-LI, and both of them were correlated with the pathological changes of the tumor.

CONCLUSION: A composite analysis of the pathological characteristics of tumor tissue, DI and PCNA-LI might be useful in predicting the prognosis of HCC patients.

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